Alterations of gut microbiota and serum bile acids are associated with parenteral nutrition-associated liver disease

Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD. M...

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Bibliographic Details
Published in:Journal of pediatric surgery 2021-04, Vol.56 (4), p.738-744
Main Authors: Wang, Nan, Wang, Jiazheng, Zhang, Tian, Huang, Liufang, Yan, Weihui, Lu, Lina, Jia, Jie, Tao, Yijing, Cai, Wei, Wang, Ying
Format: Article
Language:English
Subjects:
Bile acid profile
Cecal microbiome
Liver dysfunction
Parenteral nutrition
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Summary:Parenteral nutrition-associated liver disease (PNALD) is a major complication of long-term parenteral nutrition (PN). The pathogenesis of PNALD remains unclear. We investigated the changes in taxonomic and functional composition of gut microbiota and serum bile acid levels in a rat model of PNALD. Male 4-week-old Sprague Dawley rats received either total parenteral nutrition or standard chow with 0.9% saline for 7 days. The taxonomic composition of cecal microbiota and its functional composition associated with bile acid metabolism were measured. There were differences in taxonomic composition between the two groups. The abundance of the secondary bile acid biosynthesis pathway was higher in the TPN group (p 
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2020.06.035