Gelatin and the risk of bleeding after cardiac surgery

Background Gelatins has been used in cardiac surgery because of their ability to preserve intravascular volume better than crystalloids. Unfortunately, gelatin has been associated with impaired coagulation and hemostasis, that may cause increased bleeding. We investigated whether the administration...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2020-11, Vol.64 (10), p.1438-1445
Main Authors: Koponen, Timo, Musialowicz, Tadeusz, Lahtinen, Pasi
Format: Article
Language:English
Subjects:
Bleeding
Blood transfusion
cardiac surgery
Chest
Chest tubes
Coagulation
colloid
crystalloid
Erythrocytes
Gelatin
Heart
Heart surgery
Hemostasis
Hemostatics
intensive care unit
intravenous fluid therapy
Patients
Platelets
Surgery
Surgical drains
Wound drainage
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Summary:Background Gelatins has been used in cardiac surgery because of their ability to preserve intravascular volume better than crystalloids. Unfortunately, gelatin has been associated with impaired coagulation and hemostasis, that may cause increased bleeding. We investigated whether the administration of gelatin increases postoperative bleeding after cardiac surgery. Methods Retrospective, observational single‐center cohort study in the intensive care unit of a tertiary teaching hospital. Postoperative bleeding, chest tube drainage volume and consumption of blood products were compared between groups. Results Cohort included 3067 consecutive patients who underwent cardiac surgery. First 1698 patients received gelatin (gelatin group), and 1369 patients did not (crystalloid group). The characteristics of the patients in the gelatin and crystalloid groups were comparable. Postoperative chest tube drainage was 18% (95% CI 11%‐20%) greater during the first 12 hours (P 
ISSN:0001-5172
1399-6576
DOI:10.1111/aas.13677