Investigating the effects of walnut ointment on non-healing burn wounds

• Published in: Burns 2021-03, Vol.47 (2), p.455-465
• Main Authors: Chen, Qian, Deng, Xingwang, Qiang, Lijuan, Yao, Ming, Guan, Lifeng, Xie, Nan, Zhao, Dan, Ma, Jiaxiang, Ma, Liqiong, Wu, Yinsheng, Yan, Xie
• Format: Article
• Language: English
• Subjects: Full-thickness burn wound models; Non-healing burn wounds; Porcine; Walnut ointment; Wound healing
• ISSN: 0305-4179; 1879-1409
• DOI: 10.1016/j.burns.2020.06.032

•The walnut ointment offers an effective and economical treatment for patients presenting with non-healing burn wounds.•Porcine full-thickness burn wound models were created and applied to investigate the mechanism of enhanced wound healing by the walnut ointment.•The walnut ointment supported in vivo epidermal wound healing through promoting keratinocyte proliferation and differentiation. Effective treatments for non-healing burn wounds are an unmet need for 95% of burn sufferers. Approaches currently available to treat non-healing burn wounds are not satisfactory due to undesirable side-effects or expense. The anti-oxidation and antibacterial activities of walnuts are recommended for treating chronic diseases. Walnut ointment has been developed and successfully applied to treat non-healing burn wounds in our hospital for decades. We report herein a detailed retrospective case review examining patients’ response to the walnut ointment. The walnut ointment has shortened healing time of non-healing burn wounds and improved clinical outcomes. In order to investigate the mechanism of action, walnut ointment has been applied on wounds of porcine full-thickness burn wound models. Histological and immunohistochemical analysis indicated our walnut ointment supports wound healing through promoting keratinocyte proliferation and differentiation. Taken together, we recommend the walnut ointment offers an effective and economical treatment for patients presenting with non-healing burn wounds.