Peripheral blood morphologic findings in patients with COVID‐19

Dear Editors, Our understanding of the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the coronavirus disease 2019 (COVID‐19), is rapidly expanding.1 Peripheral blood count abnormalities are diverse and can include neutrophilia and lymphopenia,...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Laboratory Hematology 2020-12, Vol.42 (6), p.e248-e251
Main Authors: Sadigh, Sam, Massoth, Lucas R., Christensen, Bianca B., Stefely, Jonathan A., Keefe, Joan, Sohani, Aliyah R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Betacoronavirus
blood
Blood Cell Count
Blood Cells - ultrastructure
Cell Lineage
Cell Size
coronavirus
Coronavirus Infections - blood
Coronavirus Infections - therapy
COVID-19
Extracorporeal Membrane Oxygenation
Female
Hematopoiesis
Humans
Male
Middle Aged
Neutrophils - ultrastructure
Pandemics
Peripheral blood
plasma cells
Plasma Cells - ultrastructure
Pneumonia, Viral - blood
Pneumonia, Viral - therapy
SARS-CoV-2
Sensitivity and Specificity
smudged neutrophils
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dear Editors, Our understanding of the novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the coronavirus disease 2019 (COVID‐19), is rapidly expanding.1 Peripheral blood count abnormalities are diverse and can include neutrophilia and lymphopenia, or thrombocytopenia as well as thrombocytosis.2 Although there have been several case reports or small series documenting some of the morphological features seen in peripheral blood smears of patients with COVID‐19,3-7 larger series are lacking and the range of features appears to be expanding. For comparison, we analyzed smear findings in a control group of 14 confirmed COVID‐19‐negative patients randomly selected among those with blood smears available in CellaVision during the same time frame who had a total white blood cell count (WBC) of 10‐20 x109/L. Characteristics of patient cohort with COVID‐19 and control group Parameter COVID + group (N = 27) Control group (N = 14) P‐Value Age (years) Mean (range) 52.6 (28‐80) 57.5 (25‐92) .34 Sex F 10 37.0% 8 57.1% .32 M 17 63.0% 6 42.9% In ICU (Y/N) Y 22 81.5% 5 35.7% .0057 N 5 18.5% 9 64.3% on ECMO (Y/N) Y 5 18.5% 0 0.0% .15 N 22 81.5% 14 100.0% Outcome Discharged 4 14.8% 10 71.4%
ISSN:1751-5521
1751-553X
DOI:10.1111/ijlh.13300