Novel immune biomarkers in complex regional pain syndrome

We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with posit...

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Bibliographic Details
Published in:Journal of neuroimmunology 2020-10, Vol.347, p.577330-577330, Article 577330
Main Authors: Russo, Marc A., Georgius, Peter, Pires, Ananda Staats, Heng, Benjamin, Allwright, Michael, Guennewig, Boris, Santarelli, Danielle M., Bailey, Dominic, Fiore, Nathan T., Tan, Vanessa X., Latini, Alexandra, Guillemin, Gilles J., Austin, Paul J.
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Complex regional pain syndrome
Complex Regional Pain Syndromes - blood
Complex Regional Pain Syndromes - diagnosis
Complex Regional Pain Syndromes - immunology
Cytokines
Female
Humans
Inflammation
Interleukin-1 - blood
Interleukin-1 - immunology
Kynurenine
Kynurenine - blood
Kynurenine - immunology
Machine Learning
Male
Middle Aged
Pilot Projects
Tetrahydrobiopterin
Tryptophan
Tryptophan - blood
Tryptophan - immunology
Tumor Necrosis Factor-alpha - blood
Tumor Necrosis Factor-alpha - immunology
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Summary:We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF-α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores. Using machine learning, we identified a set of binary variables, including IL-37 and GM-CSF, capable of distinguishing controls from established CRPS subjects. These results suggest possible involvement of various inflammatory markers in CRPS pathogenesis. [Display omitted] •Interleukin-37 and tryptophan levels are reduced in CRPS•Tetrahydrobiopterin levels correlate with pain scores in CRPS•Kynurenine/tryptophan ratio and TNF-α levels correlate with kinesiophobia in CRPS•Xanthurenic acid and neopterin levels correlate with psychological symptoms in CRPS•Biomarkers IL-37, GM-CSF, Tregs and CD8+ T cells can distinguish CRPS from controls
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2020.577330