Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea

Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the trea...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2020-11, Vol.262, p.113190-113190, Article 113190
Main Authors: Lin, Pei-Rong, Kuo, Ping-Chung, Li, Yue-Chiun, Jhuo, Cian-Fen, Hsu, Wei-Li, Tzen, Jason T.C.
Format: Article
Language:English
Subjects:
Alphainfluenzavirus - drug effects
Alphainfluenzavirus - physiology
Animals
Antiviral Agents - isolation & purification
Antiviral Agents - pharmacology
Camellia sinensis
Cell Survival - drug effects
Cell Survival - physiology
Dogs
Humans
Kucha tea
Madin Darby Canine Kidney Cells
NS1 viral protein
Phenols - isolation & purification
Phenols - pharmacology
Plant Leaves
Strictinin
Teas, Herbal
Theacrine
Uric Acid - analogs & derivatives
Uric Acid - isolation & purification
Uric Acid - pharmacology
Viral progeny production
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Summary:Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the treatment of common cold empirically. Two extra compounds of relative abundance were detected in Kucha tea in comparison with Pu'er tea, and their chemical structures were identified as chlorogenic acid and theacrine. These two compounds as well as two major compounds, strictinin and caffeine, in Kucha tea were evaluated for their cytotoxicity and inhibitory effects on human influenza virus A/Puerto Rico/8/34 by analyzing viral protein expression and progeny production. No or low cytotoxicity was detected for the four Kucha compounds when their concentrations were below 100 μM. Expression of viral NS1 protein was significantly inhibited by chlorogenic acid, theacrine or strictinin, but not caffeine at a concentration of 100 μM. The relative inhibitory potency was detected as chlorogenic acid 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2020.113190