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Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea
Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the trea...
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| Published in: | Journal of ethnopharmacology 2020-11, Vol.262, p.113190-113190, Article 113190 |
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| container_end_page | 113190 |
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| container_title | Journal of ethnopharmacology |
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| creator | Lin, Pei-Rong Kuo, Ping-Chung Li, Yue-Chiun Jhuo, Cian-Fen Hsu, Wei-Li Tzen, Jason T.C. |
| description | Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the treatment of common cold empirically.
Two extra compounds of relative abundance were detected in Kucha tea in comparison with Pu'er tea, and their chemical structures were identified as chlorogenic acid and theacrine. These two compounds as well as two major compounds, strictinin and caffeine, in Kucha tea were evaluated for their cytotoxicity and inhibitory effects on human influenza virus A/Puerto Rico/8/34 by analyzing viral protein expression and progeny production.
No or low cytotoxicity was detected for the four Kucha compounds when their concentrations were below 100 μM. Expression of viral NS1 protein was significantly inhibited by chlorogenic acid, theacrine or strictinin, but not caffeine at a concentration of 100 μM. The relative inhibitory potency was detected as chlorogenic acid |
| doi_str_mv | 10.1016/j.jep.2020.113190 |
| format | article |
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Two extra compounds of relative abundance were detected in Kucha tea in comparison with Pu'er tea, and their chemical structures were identified as chlorogenic acid and theacrine. These two compounds as well as two major compounds, strictinin and caffeine, in Kucha tea were evaluated for their cytotoxicity and inhibitory effects on human influenza virus A/Puerto Rico/8/34 by analyzing viral protein expression and progeny production.
No or low cytotoxicity was detected for the four Kucha compounds when their concentrations were below 100 μM. Expression of viral NS1 protein was significantly inhibited by chlorogenic acid, theacrine or strictinin, but not caffeine at a concentration of 100 μM. The relative inhibitory potency was detected as chlorogenic acid < theacrine < strictinin, and both theacrine and strictinin displayed significant inhibition at a concentration of 50 μM. According to a plaque assay, viral progeny production was significantly reduced by theacrine or strictinin, but not by chlorogenic acid or caffeine under the same concentration of 100 μM.
It is suggested that theacrine and strictinin are two major ingredients responsible for the anti-influenza activity of Yunnan Kucha tea traditionally used for the treatment of common cold.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.113190</identifier><identifier>PMID: 32730889</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Alphainfluenzavirus - drug effects ; Alphainfluenzavirus - physiology ; Animals ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Camellia sinensis ; Cell Survival - drug effects ; Cell Survival - physiology ; Dogs ; Humans ; Kucha tea ; Madin Darby Canine Kidney Cells ; NS1 viral protein ; Phenols - isolation & purification ; Phenols - pharmacology ; Plant Leaves ; Strictinin ; Teas, Herbal ; Theacrine ; Uric Acid - analogs & derivatives ; Uric Acid - isolation & purification ; Uric Acid - pharmacology ; Viral progeny production</subject><ispartof>Journal of ethnopharmacology, 2020-11, Vol.262, p.113190-113190, Article 113190</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-b184601c54be187f539ab05f23f1f2c8dd57362d6b5a558b66c0d02f5c73dcbf3</citedby><cites>FETCH-LOGICAL-c353t-b184601c54be187f539ab05f23f1f2c8dd57362d6b5a558b66c0d02f5c73dcbf3</cites><orcidid>0000-0003-1123-0015</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32730889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Pei-Rong</creatorcontrib><creatorcontrib>Kuo, Ping-Chung</creatorcontrib><creatorcontrib>Li, Yue-Chiun</creatorcontrib><creatorcontrib>Jhuo, Cian-Fen</creatorcontrib><creatorcontrib>Hsu, Wei-Li</creatorcontrib><creatorcontrib>Tzen, Jason T.C.</creatorcontrib><title>Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the treatment of common cold empirically.
Two extra compounds of relative abundance were detected in Kucha tea in comparison with Pu'er tea, and their chemical structures were identified as chlorogenic acid and theacrine. These two compounds as well as two major compounds, strictinin and caffeine, in Kucha tea were evaluated for their cytotoxicity and inhibitory effects on human influenza virus A/Puerto Rico/8/34 by analyzing viral protein expression and progeny production.
No or low cytotoxicity was detected for the four Kucha compounds when their concentrations were below 100 μM. Expression of viral NS1 protein was significantly inhibited by chlorogenic acid, theacrine or strictinin, but not caffeine at a concentration of 100 μM. The relative inhibitory potency was detected as chlorogenic acid < theacrine < strictinin, and both theacrine and strictinin displayed significant inhibition at a concentration of 50 μM. According to a plaque assay, viral progeny production was significantly reduced by theacrine or strictinin, but not by chlorogenic acid or caffeine under the same concentration of 100 μM.
It is suggested that theacrine and strictinin are two major ingredients responsible for the anti-influenza activity of Yunnan Kucha tea traditionally used for the treatment of common cold.
[Display omitted]</description><subject>Alphainfluenzavirus - drug effects</subject><subject>Alphainfluenzavirus - physiology</subject><subject>Animals</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Camellia sinensis</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - physiology</subject><subject>Dogs</subject><subject>Humans</subject><subject>Kucha tea</subject><subject>Madin Darby Canine Kidney Cells</subject><subject>NS1 viral protein</subject><subject>Phenols - isolation & purification</subject><subject>Phenols - pharmacology</subject><subject>Plant Leaves</subject><subject>Strictinin</subject><subject>Teas, Herbal</subject><subject>Theacrine</subject><subject>Uric Acid - analogs & derivatives</subject><subject>Uric Acid - isolation & purification</subject><subject>Uric Acid - pharmacology</subject><subject>Viral progeny production</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPGzEUha2qFQTKD2CDvOyCSf0Yjx2xQhGPCiQ2sOjK8tjXjUeJJ7U9IPj1OApl2dXVlb5zpPMhdErJnBLa_RzmA2znjLD6U04X5AuaUSVZI4XkX9GMcKkaJVt6iI5yHgghkrbkAB1yJjlRajFD9nEFxqYQAZvocC4p2BJiiOe4vIx4Y4Yx4RD_JHABYsnY17-sdnQJTYh-PUF8M9jU1HMor3j0-PcUo4n4brIrgwuY7-ibN-sMJx_3GD1dXz0ub5v7h5tfy8v7xnLBS9NT1XaEWtH2UFd4wRemJ8Iz7qlnVjlXV3XMdb0wQqi-6yxxhHlhJXe29_wY_dj3btP4d4Jc9CZkC-u1iTBOWbOWLaRqeasqSveoTWPOCbzeprAx6VVTondu9aCrW71zq_dua-bso37qN-A-E_9kVuBiD0Ad-Rwg6WyrNFvVJbBFuzH8p_4dhyyKYA</recordid><startdate>20201115</startdate><enddate>20201115</enddate><creator>Lin, Pei-Rong</creator><creator>Kuo, Ping-Chung</creator><creator>Li, Yue-Chiun</creator><creator>Jhuo, Cian-Fen</creator><creator>Hsu, Wei-Li</creator><creator>Tzen, Jason T.C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1123-0015</orcidid></search><sort><creationdate>20201115</creationdate><title>Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea</title><author>Lin, Pei-Rong ; Kuo, Ping-Chung ; Li, Yue-Chiun ; Jhuo, Cian-Fen ; Hsu, Wei-Li ; Tzen, Jason T.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-b184601c54be187f539ab05f23f1f2c8dd57362d6b5a558b66c0d02f5c73dcbf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alphainfluenzavirus - drug effects</topic><topic>Alphainfluenzavirus - physiology</topic><topic>Animals</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Camellia sinensis</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - physiology</topic><topic>Dogs</topic><topic>Humans</topic><topic>Kucha tea</topic><topic>Madin Darby Canine Kidney Cells</topic><topic>NS1 viral protein</topic><topic>Phenols - isolation & purification</topic><topic>Phenols - pharmacology</topic><topic>Plant Leaves</topic><topic>Strictinin</topic><topic>Teas, Herbal</topic><topic>Theacrine</topic><topic>Uric Acid - analogs & derivatives</topic><topic>Uric Acid - isolation & purification</topic><topic>Uric Acid - pharmacology</topic><topic>Viral progeny production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Pei-Rong</creatorcontrib><creatorcontrib>Kuo, Ping-Chung</creatorcontrib><creatorcontrib>Li, Yue-Chiun</creatorcontrib><creatorcontrib>Jhuo, Cian-Fen</creatorcontrib><creatorcontrib>Hsu, Wei-Li</creatorcontrib><creatorcontrib>Tzen, Jason T.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Pei-Rong</au><au>Kuo, Ping-Chung</au><au>Li, Yue-Chiun</au><au>Jhuo, Cian-Fen</au><au>Hsu, Wei-Li</au><au>Tzen, Jason T.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2020-11-15</date><risdate>2020</risdate><volume>262</volume><spage>113190</spage><epage>113190</epage><pages>113190-113190</pages><artnum>113190</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Kucha tea plant (Camellia assamica var. kucha Chang et Wang) is regarded as a mutant variety of wild Pu'er tea plant found in few mountain areas of Yunnan, China. Its fresh young leaves and shoots are picked by the indigenous aborigines in these local areas to prepare an herbal tea for the treatment of common cold empirically.
Two extra compounds of relative abundance were detected in Kucha tea in comparison with Pu'er tea, and their chemical structures were identified as chlorogenic acid and theacrine. These two compounds as well as two major compounds, strictinin and caffeine, in Kucha tea were evaluated for their cytotoxicity and inhibitory effects on human influenza virus A/Puerto Rico/8/34 by analyzing viral protein expression and progeny production.
No or low cytotoxicity was detected for the four Kucha compounds when their concentrations were below 100 μM. Expression of viral NS1 protein was significantly inhibited by chlorogenic acid, theacrine or strictinin, but not caffeine at a concentration of 100 μM. The relative inhibitory potency was detected as chlorogenic acid < theacrine < strictinin, and both theacrine and strictinin displayed significant inhibition at a concentration of 50 μM. According to a plaque assay, viral progeny production was significantly reduced by theacrine or strictinin, but not by chlorogenic acid or caffeine under the same concentration of 100 μM.
It is suggested that theacrine and strictinin are two major ingredients responsible for the anti-influenza activity of Yunnan Kucha tea traditionally used for the treatment of common cold.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32730889</pmid><doi>10.1016/j.jep.2020.113190</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1123-0015</orcidid></addata></record> |
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| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2020-11, Vol.262, p.113190-113190, Article 113190 |
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| source | Elsevier |
| subjects | Alphainfluenzavirus - drug effects Alphainfluenzavirus - physiology Animals Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Camellia sinensis Cell Survival - drug effects Cell Survival - physiology Dogs Humans Kucha tea Madin Darby Canine Kidney Cells NS1 viral protein Phenols - isolation & purification Phenols - pharmacology Plant Leaves Strictinin Teas, Herbal Theacrine Uric Acid - analogs & derivatives Uric Acid - isolation & purification Uric Acid - pharmacology Viral progeny production |
| title | Theacrine and strictinin, two major ingredients for the anti-influenza activity of Yunnan Kucha tea |
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