Chemical shift imaging in the identification of those renal tumours that contain microscopic fat and the utility of multiparametric MRI in their differentiation

Introduction The aim of this study was to assess the qualitative and MRI findings of renal tumours, to determine which lesions contain microscopic fat, one of the potential differentiating factors between tumour types. Methods 73 patients who underwent 3 Tesla MRI including chemical shift imaging, w...

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Bibliographic Details
Published in:Journal of medical imaging and radiation oncology 2020-12, Vol.64 (6), p.762-768
Main Authors: Silva, Suresh, Lockhart, Kathleen, Aslan, Peter, Nash, Peter, Hutton, Anthony, Malouf, David, Lee, Dominic, Cozzi, Paul, Maclean, Fiona, Thompson, James
Format: Article
Language:English
Subjects:
Biopsy
Chemical equilibrium
Diagnosis
Diagnostic systems
Differentiation
Kidney cancer
kidney neoplasms
Lesions
Magnetic resonance imaging
Mathematical analysis
Medical imaging
radiology
surgical pathology
Tumors
urology
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Summary:Introduction The aim of this study was to assess the qualitative and MRI findings of renal tumours, to determine which lesions contain microscopic fat, one of the potential differentiating factors between tumour types. Methods 73 patients who underwent 3 Tesla MRI including chemical shift imaging, with subsequent biopsy or excision for histopathological diagnosis, were included in the study. The images were reviewed for a decrease in signal intensity (SI) on the opposed phase compared with the in‐phase gradient echo T1 images, indicating the presence of microscopic fat. The chemical shift index was then calculated as a percentage of SI change and compared with the pathological diagnosis. Results In total, 38 (52%) of lesions demonstrated a decrease in SI, consistent with microscopic fat. Microscopic fat was found in 28 (80%) clear cell renal cell carcinomas (RCCs), 6 (66.7%) angiomyolipomas, 2 (20%) papillary RCCs, 1 (20%) chromophobe RCC and 1 (9.1%) oncocytoma. Pairwise comparison of means indicated that the amount of microscopic fat was significantly larger only for angiomyolipomas compared with clear cell RCCs (P 
ISSN:1754-9477
1754-9485
DOI:10.1111/1754-9485.13082