The emerging role of lncRNAs in multiple sclerosis

• Published in: Journal of neuroimmunology 2020-10, Vol.347, p.577347-577347, Article 577347
• Main Authors: Ghaderian, Samin, Shomali, Navid, Behravesh, Soheil, Danbaran, Gholamreza Rezaei, Hemmatzadeh, Maryam, Aslani, Saeed, Jadidi-Niaragh, Farhad, Hosseinzadeh, Ramin, Torkamandi, Shahram, Mohammadi, Hamed
• Format: Article
• Language: English
• Subjects: Autoimmune diseases; Demyelination; Epigenesis, Genetic - physiology; Epithelial-Mesenchymal Transition - physiology; Humans; LncRNA; Multiple sclerosis; Multiple Sclerosis - genetics; Multiple Sclerosis - metabolism; RNA, Long Noncoding - physiology
• ISSN: 0165-5728; 1872-8421
• DOI: 10.1016/j.jneuroim.2020.577347

Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) with various clinical manifestations. The characteristic of MS is that myelin is attacked by the body's immune system and increases the electrical capacity of axons, and is the primary pathophysiological mechanism of the transmission block. Studies have shown that epigenetic factors participate in the development of MS. LncRNAs are highly abundant and heterogeneous linear RNA transcripts with lengths exceeding 200 nucleotides and no protein-coding potential. Currently, pieces of evidence have demonstrated that lncRNAs have fundamental actions in multiple cellular pathways, including immune system regulation, epithelial-mesenchymal transition (EMT), cancer cell growth and metastasis, cellular homeostasis, and embryo development. It has been demonstrated that epigenetic mechanisms have an abundant role in the pathogenesis of MS in which the role of lncRNAs as epigenetic regulatory molecules in molecular processes has been proven. In this paper, we have focused on the correlation between MS and lncRNAs, the role of lncRNA in the pathogenesis of the disease, and the diagnostic and prognostic potential of lncRNA in MS. •The epigenetic factors in the development of MS has recently been considered.•LncRNAs exhibit epigenetic characteristics which may lead to the initiation of MS.•Involvement of LncRNAs in the pathogenesis of MS have been proved.•LncRNAs are involved in the abnormalities immune-related signaling pathways.•Aberrant expression of lncRNAs participates in the advancement of MS via influencing immunological pathways.