Stealth Polymer-Coated Graphene Oxide Decorated Mesoporous Titania Nanoplatforms for In Vivo Chemo-Photodynamic Cancer Therapy

• Published in: Pharmaceutical research 2020-08, Vol.37 (8), p.162-162, Article 162
• Main Authors: Gautam, Milan, Gupta, Biki, Soe, Zar Chi, Poudel, Kishwor, Maharjan, Srijan, Jeong, Jee-Heon, Choi, Han-Gon, Ku, Sae Kwang, Yong, Chul Soon, Kim, Jong Oh
• Format: Article
• Language: English
• Subjects: Antitumor activity; Biochemistry; Biocompatibility; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Cancer; Cancer therapies; Chemotherapy; Colon cancer; Colorectal cancer; Cytotoxicity; Drug delivery; Drug delivery systems; Drugs; Force and energy; Graphene; Graphite; Health aspects; Imatinib; Immunoglobulins; Medical Law; Nanocomposites; Pharmacology/Toxicology; Pharmacy; Phototherapy; Polymers; Radiation; Reactive oxygen species; Research Paper; Silica; Targeted cancer therapy; Titanium dioxide; Vehicles
• ISSN: 0724-8741; 1573-904X
• DOI: 10.1007/s11095-020-02900-1

Purpose The goal of this study was to develop chemotherapeutic drug-loaded photoactivable stealth polymer-coated silica based- mesoporous titania nanoplatforms for enhanced antitumor activity. Methods Both in vitro and in vivo models of solvothermal treated photoactivable nanoplatforms were evaluated for efficient chemo-photothermal activity. A versatile nanocomposite that combined silica based- mesoporous titania nanocarriers (S-MTN) with the promising photoactivable agent, graphene oxide (G) modified with a stealth polymer (P) was fabricated to deliver chemotherapeutic agent, imatinib (I), (referred as S-MTN@IG-P) for near-infrared (NIR)-triggered drug delivery and enhanced chemo-photothermal therapy. Results The fabricated S-MTN@IG-P nanoplatform showed higher drug loading (~20%) and increased drug release (~60%) in response to light in acidic condition (pH 5.0). As prepared nanoplatform significantly converted NIR light into thermal energy (43.2°C) to produce reactive oxygen species (ROS). The pronounced cytotoxic effect was seen in both colon cancer cells (HCT-116 and HT-29) that was mediated through the chemotherapeutic effect of imatinib and the photothermal and ROS generation effects of graphene oxide. In vivo study also showed that S-MTN@IG-P could significantly accumulate into the tumor area and suppress the tumor growth under NIR irradiation without any biocompatibility issues. Conclusion Cumulatively, the above results showed promising effects of S-MTN@IG-P for effective chemo-phototherapy of colon cancer.