Noninvasive real-time detection of cerebral blood perfusion in hemorrhagic shock rabbits based on whole-brain magnetic induction phase shift: an experimental study

• Published in: Physiological measurement 2020-09, Vol.41 (9), p.095004-095004
• Main Authors: Pan, Wencai, Zhuang, Wei, Chong, Yinbao, Qin, Mingxin, Li, Yang, Xiao, Jingjing, Wang, Qing, Zhang, Shihui, Zhao, Shuanglin, Zhao, Peng
• Format: Article
• Language: English
• Subjects: Animals; Brain - diagnostic imaging; cerebral blood perfusion; Cerebrovascular Circulation; hemorrhagic shock; magnetic induction phase shift; Magnetic Phenomena; noninvasive detection; Perfusion; Rabbits; Shock, Hemorrhagic - diagnosis
• ISSN: 0967-3334; 1361-6579
• DOI: 10.1088/1361-6579/abad12

Objective: This study aimed to perform experiments to investigate the change trend in brain magnetic induction phase shift (MIPS) during hemorrhagic shock of different degrees of severity and to find the correlation between brain MIPS value and commonly used physiological indicators for detecting shock so as to explore a noninvasive method suitable for prehospital real-time detection of cerebral blood perfusion in hemorrhagic shock. Approach: The self-developed MIPS detection system was used to monitor the brain MIPS value in the whole process of hemorrhagic shock models of rabbits with different degrees of severity (control, mild, moderate, and severe) of shock in real time. Meanwhile, common physiological parameters, including arterial blood lactate (ABL), mean arterial pressure (MAP), heart rate (HR),core body temperature (CBT), regional cerebral blood flow (rCBF), and electroencephalogram (EEG), were also evaluated. Main results: The findings suggested that the brain MIPS value showed a downward trend in the shock process, and the decline degree of the MIPS value positively correlated with the severity of shock. Moreover, it showed a good detection and resolution ability in time/process and severity (P < 0.05). The MIPS values significantly correlated with ABL (P < 0.01), CBT (P < 0.01), and EEG (P < 0.05) at all four shock levels; with MAP (P < 0.05) and rCBF (P < 0.05) in the control, moderate, and severe groups; and with HR (P < 0.01) only in the severe group. Significance: The results demonstrated that the brain MIPS value has the capability of detecting hemorrhagic shock. The MIPS technique is a noninvasive method suitable for prehospital real-time detection of cerebral blood perfusion in hemorrhagic shock.