Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus

Four new prenylflavonol glycosides (1-4) along with two known analogues (5-6) were isolated from the leaves of Cyclocarya paliurus for the first time. The structures of these compounds were characterized by comprehensive analysis of 1 D, 2 D NMR, HRESIMS, UV data and enzymatic hydrolysis. In bioassa...

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Bibliographic Details
Published in:Natural product research 2022-02, Vol.36 (3), p.772-779
Main Authors: Ye, Zi-Jun, Sun, Hui-Hui, Chen, Zu-Hui, Wu, Jian-Ping, Li, Jing, Zhu, Hui, Huang, Lu-Lu, Chang, Xi-Wen, Ou, Sai-Yu, Wang, Wen-Xuan, He, Xiao-Ai, Zhu, Gang-Zhi, Xu, Kang-Ping
Format: Article
Language:English
Subjects:
Cyclocarya paliurus
Glycosides - pharmacology
Juglandaceae
nitric oxide
Plant Leaves
prenylflavonol glycosides
RAW264.7 cells
Triterpenes
Xanthine Oxidase
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Summary:Four new prenylflavonol glycosides (1-4) along with two known analogues (5-6) were isolated from the leaves of Cyclocarya paliurus for the first time. The structures of these compounds were characterized by comprehensive analysis of 1 D, 2 D NMR, HRESIMS, UV data and enzymatic hydrolysis. In bioassays, compounds 1-4 were evaluated for inhibitory effects on xanthine oxidase (XOD) and effects on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) induced RAW264.7 cells. Moreover, compounds 1 and 2 showed outstanding XOD inhibitions with IC 50 values of 18.16 ± 3.91 and 37.65 ± 5.67 µM, and exhibited inhibitions against LPS-induced NO production with IC 50 values of 80.50 ± 3.09 and 82.28 ± 2.87 µM.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1803313