Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjects

Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in...

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Bibliographic Details
Published in:Psychological medicine 2022-04, Vol.52 (6), p.1069-1079
Main Authors: Nenadić, Igor, Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Mosebach, Johannes, Ettinger, Ulrich, Grant, Phillip, Meinert, Susanne, Opel, Nils, Lemke, Hannah, Fingas, Stella, Förster, Katharina, Hahn, Tim, Jansen, Andreas, Andlauer, Till F. M., Forstner, Andreas J., Heilmann-Heimbach, Stefanie, Hall, Alisha S. M., Awasthi, Swapnil, Ripke, Stephan, Witt, Stephanie H., Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M., Dannlowski, Udo, Krug, Axel, Streit, Fabian, Kircher, Tilo
Format: Article
Language:English
Subjects:
Affective disorders
Bipolar Disorder
Blood & organ donations
Blood donors
Donors
Emotional disorders
Genetic susceptibility
Genomes
Genotype & phenotype
Hallucinations
Humans
Mental disorders
Multicenter studies
Original Article
Personality disorders
Phenotype
Phenotypes
Polygenic inheritance
Population
Psychosis
Psychotic Disorders - psychology
Quantitative psychology
Questionnaires
Schizophrenia
Schizophrenia - genetics
Schizotypal personality
Schizotypal Personality Disorder - psychology
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Summary:Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors. We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy. This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
ISSN:0033-2917
1469-8978
DOI:10.1017/S0033291720002822