Acidity and Glutathione Dual‐Responsive Polydopamine‐Coated Organic‐Inorganic Hybrid Hollow Mesoporous Silica Nanoparticles for Controlled Drug Delivery

Controversial biodegradability and nonspecific pre‐drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic‐inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultane...

Full description

Saved in:
Bibliographic Details
Published in:ChemMedChem 2020-10, Vol.15 (20), p.1940-1946
Main Authors: Chen, Qi, Chen, Yunna, Zhang, Wenjing, Huang, Qianqian, Hu, Mengru, Peng, Daiyin, Peng, Can, Wang, Lei, Chen, Weidong
Format: Article
Language:English
Subjects:
Acidity
Anticancer properties
Antitumor activity
Biodegradability
Biodegradation
Cancer
Cancer therapies
cancer treatment
Cell proliferation
Controlled release
Degradation
Drug delivery
Drug delivery systems
Glutathione
GSH-responsive
hollow mesoporous silica nanoparticles
Morphology
Nanoparticles
paclitaxel
pH-sensitive
Silica
Silicon dioxide
Stability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Controversial biodegradability and nonspecific pre‐drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic‐inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultaneously achieve enhanced biodegradability and controllable drug release. The morphology and chemical structure of the nanoparticles were characterized by TEM, N2 adsorption‐desorption isotherms, TEM‐mapping and XPS. Moreover, the release behavior of nanoparticles under various pH conditions and the degradation behavior in the presence of GSH were evaluated. With effective controlled release, HMONs‐PTX@PDA were shown to significantly inhibit cancer cell proliferation and achieve antitumor effects in vivo through dual‐response release in the tumor microenvironment. Overall, this nanoplatform has significant potential to achieve tumor microenvironment‐responsive degradation and release to enhance tumor accumulation, which is very promising for cancer treatment. Responsive and effective: We developed organic‐inorganic hybridized hollow mesoporous silica nanoparticles. The pH‐sensitive PDA film acted as a gatekeeper and responded to the weakly acidic environment of the tumor site. The disulfide bond was incorporated into the silica framework to rapidly biodegrade in the reducing tumor microenvironment.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202000263