Exosomes from human umbilical cord Mesenchymal stem cells attenuates stress-induced hippocampal dysfunctions

Human Mesenchymal Stem Cells (MSCs) especially human umbilical cord MSCs is the novel regenerative cell resource for regenerative therapy. However, the biological underpinning of MSCs in neuroprotections requires deep understanding. Exosomes is an important biological factor due to its multiple type...

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Bibliographic Details
Published in:Metabolic brain disease 2020-12, Vol.35 (8), p.1329-1340
Main Authors: Niu, Yuhu, Wang, Xiuwei, Li, Meining, Niu, Bo
Format: Article
Language:English
Subjects:
Adiponectin
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain
Cell differentiation
Central nervous system
Cognition & reasoning
Cognitive ability
Exosomes
Hippocampus
Injection
Mesenchymal stem cells
Metabolic Diseases
Metabolism
Neural stem cells
Neurogenesis
Neurology
Neuroprotection
Neurosciences
Oncology
Original Article
Stem cell transplantation
Stem cells
Umbilical cord
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Summary:Human Mesenchymal Stem Cells (MSCs) especially human umbilical cord MSCs is the novel regenerative cell resource for regenerative therapy. However, the biological underpinning of MSCs in neuroprotections requires deep understanding. Exosomes is an important biological factor due to its multiple types of contents with various biological function. In current study, we collected the exosome from umbilical cord mesenchymal stem cells (hUC-MSCs) and tested the neuroprotective effects to brain stress. Proteomic analysis indicates significant enriched protein components display the functions in metabolic regulation. We then injected the exosome (MSC-Ex) to adult mice by i.v injection. On physiological level, treatment of MSC-Ex increased the adiponectin level in peripheral central nervous system (CNS). Moreover, MSC-Ex significantly accelerated the differentiation of adult neural stem cells but did not benefit the related cognitive behavior. We then created acute brain disorder model with STZ intra-hippocampal injection. Compared with STZ group, treatment of MSC-Ex improved cognitive function. Moreover, MSC-Ex promotes hippocampal neurogenesis that was suppressed by STZ injection. In conclusion, hUC-MSCs derived exosome would exert the neural regenerative effects associating with its metabolism regulatory capacity.
ISSN:0885-7490
1573-7365
DOI:10.1007/s11011-019-00514-0