Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project

• Published in: JAMA : the journal of the American Medical Association 2020-09, Vol.324 (11), p.1078-1097
• Main Authors: Greer, David M, Shemie, Sam D, Lewis, Ariane, Torrance, Sylvia, Varelas, Panayiotis, Goldenberg, Fernando D, Bernat, James L, Souter, Michael, Topcuoglu, Mehmet Akif, Alexandrov, Anne W, Baldisseri, Marie, Bleck, Thomas, Citerio, Giuseppe, Dawson, Rosanne, Hoppe, Arnold, Jacobe, Stephen, Manara, Alex, Nakagawa, Thomas A, Pope, Thaddeus Mason, Silvester, William, Thomson, David, Al Rahma, Hussain, Badenes, Rafael, Baker, Andrew J, Cerny, Vladimir, Chang, Cherylee, Chang, Tiffany R, Gnedovskaya, Elena, Han, Moon-Ku, Honeybul, Stephen, Jimenez, Edgar, Kuroda, Yasuhiro, Liu, Gang, Mallick, Uzzwal Kumar, Marquevich, Victoria, Mejia-Mantilla, Jorge, Piradov, Michael, Quayyum, Sarah, Shrestha, Gentle Sunder, Su, Ying-ying, Timmons, Shelly D, Teitelbaum, Jeanne, Videtta, Walter, Zirpe, Kapil, Sung, Gene
• Format: Article
• Language: English
• Subjects: Apnea - diagnosis; Biomedical Research; Brain; Brain death; Brain Death - diagnosis; Brain Death - physiopathology; Brain Stem - physiopathology; Coma - diagnosis; Death; Diagnosis, Differential; Humans; Mortality; Nervous System Physiological Phenomena
• ISSN: 0098-7484; 1538-3598
• DOI: 10.1001/jama.2020.11586

IMPORTANCE: There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries. OBJECTIVE: To formulate a consensus statement of recommendations on determination of BD/DNC based on review of the literature and expert opinion of a large multidisciplinary, international panel. PROCESS: Relevant international professional societies were recruited to develop recommendations regarding determination of BD/DNC. Literature searches of the Cochrane, Embase, and MEDLINE databases included January 1, 1992, through April 2020 identified pertinent articles for review. Because of the lack of high-quality data from randomized clinical trials or large observational studies, recommendations were formulated based on consensus of contributors and medical societies that represented relevant disciplines, including critical care, neurology, and neurosurgery. EVIDENCE SYNTHESIS: Based on review of the literature and consensus from a large multidisciplinary, international panel, minimum clinical criteria needed to determine BD/DNC in various circumstances were developed. RECOMMENDATIONS: Prior to evaluating a patient for BD/DNC, the patient should have an established neurologic diagnosis that can lead to the complete and irreversible loss of all brain function, and conditions that may confound the clinical examination and diseases that may mimic BD/DNC should be excluded. Determination of BD/DNC can be done with a clinical examination that demonstrates coma, brainstem areflexia, and apnea. This is seen when (1) there is no evidence of arousal or awareness to maximal external stimulation, including noxious visual, auditory, and tactile stimulation; (2) pupils are fixed in a midsize or dilated position and are nonreactive to light; (3) corneal, oculocephalic, and oculovestibular reflexes are absent; (4) there is no facial movement to noxious stimulation; (5) the gag reflex is absent to bilateral posterior pharyngeal stimulation; (6) the cough reflex is absent to deep tracheal suctioning; (7) there is no brain-mediated motor response to noxious stimulation of the limbs; and (8) spontaneous respirations are not observed when apnea test targets reach pH