GFRα‐1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini‐review

Identification of the specific biomarkers is of great importance to enrich and expand the gonocytes or spermatogonial stem cells (SSCs) in livestock. The glial cell line‐derived neurotrophic factor (GDNF) family receptor alpha‐1 (GFRα‐1) is a conserved marker of the gonocytes/SSCs in multiple specie...

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Bibliographic Details
Published in:Anatomia, histologia, embryologia histologia, embryologia, 2021-01, Vol.50 (1), p.13-14
Main Author: Zhang, Xue‐Ming
Format: Article
Language:English
Subjects:
Cattle
GDNF family receptor alpha‐1 (GFRα‐1)
Glial cell line-derived neurotrophic factor
glial cell line‐derived neurotrophic factor (GDNF)
gonocyte
Livestock
Neuronal-glial interactions
Spermatogonia
spermatogonial stem cells (SSCs)
Stem cell transplantation
Stem cells
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Summary:Identification of the specific biomarkers is of great importance to enrich and expand the gonocytes or spermatogonial stem cells (SSCs) in livestock. The glial cell line‐derived neurotrophic factor (GDNF) family receptor alpha‐1 (GFRα‐1) is a conserved marker of the gonocytes/SSCs in multiple species including rodents, primates and human; however, its expression in bovine gonocytes/SSCs is debated. Recently, we and other teams clearly demonstrated the expression of GFRα‐1 in bovine gonocytes/SSCs. This is useful for bovine gonocytes/SSCs‐related research or application. Nonetheless, new methods still need to be developed to identify the undifferentiated spermatogonial subsets in large livestock and elucidate their spermatogenic potency.
ISSN:0340-2096
1439-0264
DOI:10.1111/ahe.12601