Relationship between serrated polyps and synchronous and metachronous advanced neoplasia: A retrospective study

• Published in: Journal of digestive diseases 2020-10, Vol.21 (10), p.558-565
• Main Authors: Tao, En‐Wei, Wang, Yong Feng, Zou, Tian Hui, Cui, Yun, Chen, Ying Xuan, Gao, Qin Yan
• Format: Article
• Language: English
• Subjects: Colorectal cancer; Colorectal carcinoma; colorectal neoplasms; Endoscopy; Gastroenterology; metachronous advanced neoplasia, serrated polyps, synchronous advanced neoplasia; Polyps
• ISSN: 1751-2972; 1751-2980
• DOI: 10.1111/1751-2980.12928

Objective Serrated polyps (SP) are regarded as precursor lesions of colorectal cancer (CRC). We conducted this single‐center study aiming to investigate the relationship between SP and synchronous and metachronous advanced neoplasia in the Chinese population. Methods The data for this retrospective study were collected from the Endoscopy Center and Department of Gastroenterology of Renji Hospital, School of Medicine, Shanghai Jiao Tong University between May 2012 and May 2019. Altogether 2205 patients were pathologically confirmed with colorectal SP. Results The detection rate of SP among all polyps has gradually increased since 2014 and reached 8.74% by 2019. Among all the SP cases, 1540 (69.84%) were confirmed as having hyperplasic polyps (HP), 486 (22.04%) were having sessile serrated lesions (SSL), and 171 (7.76%) had traditional serrated adenomas (TSA). Compared with HP (2.14%), SSL and TSA were larger and more likely to be accompanied by synchronous and metachronous advanced neoplasia (6.79% and 6.08%). We next found that large SP (diameter ≥10 mm) (odds ratio [OR] 2.52, 95% confidence interval [CI] 1.40‐4.55, P = 0.002) and SSL with high‐grade intraepithelial neoplasia (OR 13.85, 95% CI 3.28‐58.56, P