Confounded by obesity and modulated by urinary uric acid excretion, sleep‐disordered breathing indirectly relates to hyperuricaemia in males: A structural equation model

Sleep‐disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chroni...

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Bibliographic Details
Published in:Journal of sleep research 2021-06, Vol.30 (3), p.e13108-n/a
Main Authors: Lai, Ching‐Hsiang, Huang, Ren‐Jing, Wong, James Kok‐Suh, Chang, Shen‐Wen, Chung, Ai‐Hui, Chi, Yung‐Chun, Yu, Yi‐Chen, Lee, Shin‐Da, Ting, Hua
Format: Article
Language:English
Subjects:
hepatic dysfunction
metabolic syndrome
obstructive sleep apnea
renal dysfunction
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Summary:Sleep‐disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community‐based males (mean [SD] age 46.2 [7.4] years), we cross‐sectionally analysed measures of anthropometry; self‐reported lifestyle habits; overnight sleep polysomnography data; cardiopulmonary exercise tests; and biomarkers of cardiometabolic, hepatic, and renal functions; and CSI, using structural equation modelling. Objective disrupted sleep, C‐reactive protein, low physical fitness, and sedentary lifestyle were not related to UA levels in univariate analysis and were excluded. The latent variables (with corresponding manifest variables) obesity (body mass index, waist–hip ratio), hypertension (post‐sleep systolic, diastolic blood pressure), dyslipidaemia (total cholesterol, triglyceride/high‐density lipoprotein cholesterol), hepatic dysfunction (alanine aminotransferase, aspartate transaminase), and renal dysfunction (blood urea nitrogen, serum creatinine) were positively; and hyperglycaemia (fasting glucose, glycated haemoglobin) was negatively associated with hyperuricaemia (serum UA), except for SDB (Apnea–Hypopnea Index, percentage of oxygen saturation
ISSN:0962-1105
1365-2869
DOI:10.1111/jsr.13108