Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells

[Display omitted] In this manuscript we have documented the identification of a novel anticancer scaffold 3-(benzofuran-2-ylmethyl)-1H-indole. This scaffold has been designed by tweaking the known bisindolylmethane scaffold of natural products that display a wide range of biological activities. A se...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2020-10, Vol.30 (19), p.127431-127431, Article 127431
Main Authors: Siddiqui, Shaziyaparveen K., SahayaSheela, Vinodh J., Kolluru, Srinivas, Pandian, Ganesh N., Santhoshkumar, Thankayyan R., Dan, Vipin M., Ramana, Chepuri V.
Format: Article
Language:English
Subjects:
Autophagy
Benzofuran
Bisindolylmethane
Cervical cancer
Friedel-Crafts alkylation
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Summary:[Display omitted] In this manuscript we have documented the identification of a novel anticancer scaffold 3-(benzofuran-2-ylmethyl)-1H-indole. This scaffold has been designed by tweaking the known bisindolylmethane scaffold of natural products that display a wide range of biological activities. A series of 24 new conjugates have been synthesized and among them 5 derivatives exhibited IC50 values less than 40 µM against two cervical cancer cell lines SiHa and C33a. Further mechanistic studies of two compounds 3eb and 3ec revealed that the toxicity of these compounds was due to the effective induction of autophagy mediated cell death. The autophagy induction was confirmed by the progressive conversion of LC3I to LC3II and downregulation of p62 in cervical cancer cells.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2020.127431