Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis

Fatigue is a particularly common and troubling symptom that has a negative impact on quality of life throughout all phases of treatment and stages of the illness among patients with cancer. The objective of this meta-analysis is to examine the present status of fatigue prevalence in patients with ca...

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Published in:Journal of pain and symptom management 2021-01, Vol.61 (1), p.167-189.e14
Main Authors: Al Maqbali, Mohammed, Al Sinani, Mohammed, Al Naamani, Zakariya, Al Badi, Khalid, Tanash, Mu'ath Ibrahim
Format: Article
Language:English
Subjects:
Analysis
Cancer
Fatigue
Gynecological cancer
Meta-analysis
Prevalence
Quality of life
Systematic review
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description Fatigue is a particularly common and troubling symptom that has a negative impact on quality of life throughout all phases of treatment and stages of the illness among patients with cancer. The objective of this meta-analysis is to examine the present status of fatigue prevalence in patients with cancer. The following databases were searched: PubMed, MEDLINE, EMBASE, PsycINFO, Cochrane Library, from inception up to February 2020. Prevalence rates were pooled with meta-analysis using a random-effects model. Heterogeneity was tested using I-squared (I2) statistics. A total of 129 studies (N = 71,568) published between 1993 and 2020 met the inclusion criteria. The overall prevalence of fatigue was 49% (34,947 of 71,656 participants, 95% CI = 45–53) with significant heterogeneity between studies (P 
doi_str_mv 10.1016/j.jpainsymman.2020.07.037
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Fatigue prevalence rates were 62% during treatment and 51% during mixed treatment status. The prevalence of fatigue decreased from 64% in studies published from 1996 to 2000 to 43% in studies published from 2016 to 2020. Metaregression identified female gender as a significant moderator for higher prevalence of fatigue, whereas mean age is not associated with fatigue. 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Fatigue prevalence rates were 62% during treatment and 51% during mixed treatment status. The prevalence of fatigue decreased from 64% in studies published from 1996 to 2000 to 43% in studies published from 2016 to 2020. Metaregression identified female gender as a significant moderator for higher prevalence of fatigue, whereas mean age is not associated with fatigue. 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source Applied Social Sciences Index & Abstracts (ASSIA); ScienceDirect Journals
subjects Analysis
Cancer
Fatigue
Gynecological cancer
Meta-analysis
Prevalence
Quality of life
Systematic review
title Prevalence of Fatigue in Patients With Cancer: A Systematic Review and Meta-Analysis
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