TNM staging for GIT cancers is correlated with the level of MMPs and TGF-β1

• Published in: Clinical and experimental medicine 2020-11, Vol.20 (4), p.545-555
• Main Authors: El-Ashmawy, Nahla E., Khedr, Naglaa F., Mansour, Mohamed G., Al-Ashmawy, Ghada M.
• Format: Article
• Language: English
• Subjects: Cancer; Colorectal carcinoma; Enzyme-linked immunosorbent assay; Gelatinase B; Hematology; Internal Medicine; Lymph nodes; Matrilysin; Matrix metalloproteinase; Medicine; Medicine & Public Health; Metastases; Oncology; Original Article; Pancreas; Pancreatic cancer; Serum levels; Transforming growth factor-b1
• ISSN: 1591-8890; 1591-9528
• DOI: 10.1007/s10238-020-00651-2

Gastrointestinal (GIT) cancers represent the third common cancers worldwide, characterized by rapid progression and higher mortality rate. Matrix metalloproteinases (MMPs) play an important role in cancer metastases. The present study was conducted to estimate and evaluate the role of MMP-7, -9, -10 and -12 and TGF β1 along with conventional biomarkers (CEA and CA19-9) in gastric (GC), pancreatic (PC) and colorectal cancer (CRC) staging system according to tumor size (T), included lymph node (N) and metastasis (M). Seventy-five patients were divided into GC group ( n  = 25), PC group ( n  = 25), CRC group ( n  = 25) and twenty-five healthy subjects (control group). Serum levels of MMP-7, -10 and -12 were assayed simultaneously using luminex multiplex technique. Also, MMP-9, TGF-β1, CA19-9 and CEA were determined by ELISA. MMP-7,-9,-10, -12, TGF-β1 and CEA levels were significantly ( p