Placebo effect of rTMS on post-stroke motor rehabilitation: a meta-analysis

Previous studies have shown that placebo repetitive transcranial magnetic stimulation (rTMS) was effective on post-stroke motor rehabilitation. However, the placebo effect has not been systematically assessed. Therefore, this meta-analysis was conducted to resolve this issue and explore potential in...

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Bibliographic Details
Published in:Acta neurologica Belgica 2021-08, Vol.121 (4), p.993-999
Main Authors: Jin, Yu, Pu, Ting, Guo, Zhiwei, Jiang, Binghu, Mu, Qiwen
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Follow-Up Studies
Humans
Medicine/Public Health
Motor Skills - physiology
Neurology
Neuroradiology
Neurosciences
Original Article
Placebo Effect
Randomized Controlled Trials as Topic - methods
Stroke - diagnosis
Stroke - physiopathology
Stroke - therapy
Stroke Rehabilitation - methods
Transcranial Magnetic Stimulation - methods
Treatment Outcome
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Summary:Previous studies have shown that placebo repetitive transcranial magnetic stimulation (rTMS) was effective on post-stroke motor rehabilitation. However, the placebo effect has not been systematically assessed. Therefore, this meta-analysis was conducted to resolve this issue and explore potential influencing factors further. PubMed, Embase, web of science and the Cochrane Library were searched for published randomised controlled trials (RCTs) with placebo rTMS treatment of stroke recovery until May 2019. The placebo effect size (Hedges’ g) was estimated using the motor outcome of pre- and post- placebo rTMS treatment. Meta-regression analysis was also performed to explore potential influencing factors for the placebo effect. Twenty-six placebo-controlled trials (including 381 patients in placebo group) were selected. Effect size results (Hedges’ g  = 0.466, 95% CI 0.207–0.726; P  
ISSN:0300-9009
2240-2993
DOI:10.1007/s13760-020-01460-w