Natural products present neurotrophic properties in neurons of the limbic system in aging rodents

Aging is a complex process that can lead to neurodegeneration and, consequently, several pathologies, including dementia. Physiological aging leads to changes in several body organs, including those of the central nervous system (CNS). Morphological changes in the CNS and particularly the brain resu...

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Bibliographic Details
Published in:Synapse (New York, N.Y.) N.Y.), 2021-02, Vol.75 (2), p.e22185-n/a
Main Authors: Flores, Gonzalo, Flores‐Gómez, Gabriel Daniel, Díaz, Alfonso, Penagos‐Corzo, Julio César, Iannitti, Tommaso, Morales‐Medina, Julio César
Format: Article
Language:English
Subjects:
Aging
apamin
caffeine
Central nervous system
cerebrolysin
Circadian rhythms
Cognitive ability
curcuma
Dementia disorders
Drug development
Limbic system
Natural products
Neurodegeneration
neuronal morphology
Resveratrol
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Summary:Aging is a complex process that can lead to neurodegeneration and, consequently, several pathologies, including dementia. Physiological aging leads to changes in several body organs, including those of the central nervous system (CNS). Morphological changes in the CNS and particularly the brain result in motor and cognitive deficits affecting learning and memory and the circadian cycle. Characterizing neural modifications is critical to designing new therapies to target aging and associated pathologies. In this review, we compared aging to the changes occurring within the brain and particularly the limbic system. Then, we focused on key natural compounds, apamin, cerebrolysin, Curcuma longa, resveratrol, and N‐PEP‐12, which have shown neurotrophic effects particularly in the limbic system. Finally, we drew our conclusions delineating future perspectives for the development of novel natural therapeutics to ameliorate aging‐related processes. Brain aging is a natural complex process that involves some cognitive deficits. Neuronal aging also implies a reduction in synaptic communications. Aging is accompanied by inflammatory processes, oxidative stress and apoptosis. In the present review, all these changes in cerebral aging are analyzed. The effect of various products on brain aging is also analyzed. Abbreviations: BLA, basolateral amygdala;, DM, dorsomedial; NAcc, nucleus accumbens; PFC, prefrontal cortex; VP, ventral pallidum.
ISSN:0887-4476
1098-2396
DOI:10.1002/syn.22185