Comparison of MOG and AQP4 antibody seroprevalence in Korean adults with inflammatory demyelinating CNS diseases

We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a liv...

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Bibliographic Details
Published in:Multiple sclerosis 2021-05, Vol.27 (6), p.964-967
Main Authors: Hyun, Jae-Won, Lee, Hye Lim, Jeong, Woo Kyo, Lee, Hye Jung, Shin, Jong Hwa, Min, Ju-Hong, Kim, Byoung Joon, Kim, Seung Woo, Shin, Ha Young, Oh, Jeeyoung, Kim, Woojun, Shin, Hyun-June, Oh, Sun-Young, Kim, Hyunjin, Lim, Young-Min, Huh, So-Young, Cho, Eun Bin, Nam, Tai-Seung, Lee, Seung-Han, Kim, Sun-Young, Kang, Sa-Yoon, Han, Suk Geun, Sohn, Eun Hee, Baek, Seol-Hee, Kim, Byung-Jo, Lee, Sang-Soo, Seok, Jin Myoung, Hong, Yoon-Ho, Oh, Seong-il, Kim, Jong Kuk, Shin, Kyong Jin, Kwon, Ohyun, Cho, Joong-Yang, Bae, Jong Seok, Kim, So Yeon, Kim, Yeseul, Lee, Min Young, Kim, Su-Hyun, Kim, Ho Jin
Format: Article
Language:English
Subjects:
Antibodies
Aquaporin 4
Central nervous system
Demyelinating diseases
Demyelination
Myelin
Oligodendrocyte-myelin glycoprotein
Serology
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Summary:We aimed to compare seroprevalence of anti-myelin oligodendrocyte glycoprotein (MOG) and anti-aquaporin-4 (AQP4) antibodies in Korean adults with inflammatory demyelinating diseases (IDDs) of the central nervous system (CNS), based on a multicenter nationwide database. Sera were analyzed using a live cell–based assay for MOG and AQP4 antibodies. Of 586 Korean adults with IDDs of the CNS, 36 (6.1%) and 185 (31.6%) tested positive for MOG and AQP4 antibodies, respectively. No participant showed double positivity. Seroprevalence of MOG antibodies was about five times lower than that of AQP4 antibodies in a large cohort of Korean adults with IDDs of the CNS.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458520948213