Meta-analysis of Left Atrial Appendage Closure Versus Anticoagulation in Patients With Atrial Fibrillation

[...]a growing number of patients have a contraindication or are deemed inappropriate for long-term OAC therapy1 and therefore an alternative mechanical strategy to prevent left atrial appendage (LAA) thrombus migration has emerged to treat this population. Compared with OAC, LAAC was associated wit...

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Bibliographic Details
Published in:The American journal of cardiology 2020-10, Vol.132, p.181-182
Main Authors: Kheiri, Babikir, Kumar, Kris, Simpson, Timothy F., Osman, Mohammed, Dalouk, Khidir, Beitinjaneh, Bassel, Golwala, Harsh, Henrikson, Charles A.
Format: Article
Language:English
Subjects:
Antagonists
Anticoagulants
Bleeding
Cardiac arrhythmia
Embolism
Embolisms
Fibrillation
Ischemia
Meta-analysis
Mortality
Patients
Stroke
Thromboembolism
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Summary:[...]a growing number of patients have a contraindication or are deemed inappropriate for long-term OAC therapy1 and therefore an alternative mechanical strategy to prevent left atrial appendage (LAA) thrombus migration has emerged to treat this population. Compared with OAC, LAAC was associated with a statistically significant reduction of all-cause death (incident-rate-ratio = 0.74, 95% CI 0.56 to 0.99, p = 0.02; HR 0.73, 95% CI 0.56 to 0.97, p = 0.03; absolute-risk-difference = 2.6%) and cardiovascular death (HR 0.63, 95% CI 0.42 to 0.94, p = 0.02). [...]in selected patients with nonvalvular AF, LAAC is associated with lower all-cause and cardiovascular death, and nonprocedural bleeding without increased ischemic events.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2020.07.022