Gingival tissue autophagy pathway gene expression profiles in periodontitis and aging

Objective We hypothesized that autophagy‐related genes will be differentially expressed in periodontitis, suggesting an impaired gingival autophagic response associated with disease. Background Autophagy is a cellular physiologic mechanism to maintain tissue homeostasis, while deficient autophagic r...

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Bibliographic Details
Published in:Journal of periodontal research 2021-01, Vol.56 (1), p.34-45
Main Authors: Ebersole, Jeffrey L., Kirakodu, Sreenatha, Novak, Michael J., Dawson, Dolph, Stromberg, Arnold J., Orraca, Luis, Gonzalez‐Martinez, Janis, Burgos, Armando, Gonzalez, Octavio A.
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Aging
Aging - genetics
Animals
Autophagy
Autophagy - genetics
Dentistry
Gene expression
Gingiva
Gum disease
Homeostasis
Inflammation
nonhuman primates
Periodontal diseases
Periodontitis
Periodontitis - genetics
Phagocytosis
Ribonucleic acid
RNA
Sexually transmitted diseases
STD
TOR protein
Transcriptome - genetics
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Summary:Objective We hypothesized that autophagy‐related genes will be differentially expressed in periodontitis, suggesting an impaired gingival autophagic response associated with disease. Background Autophagy is a cellular physiologic mechanism to maintain tissue homeostasis, while deficient autophagic responses increase inflammation and susceptibility to infection. Methods Rhesus monkeys [
ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12789