Tissue-based long non-coding RNAs “PVT1, TUG1 and MEG3” signature predicts Cisplatin resistance in ovarian Cancer

The current study aimed to investigate the potentiality of three lncRNAs “Plasmacytoma variant translocation 1(lnc-PVT1), Taurine upregulated gene type 1(lnc-TUG1) and Maternally expressed gene 3 (lnc-MEG-3)”, to predict Cisplatin resistance in ovarian cancer (OC), in addition, to access their progn...

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Published in:Genomics (San Diego, Calif.) Calif.), 2020-11, Vol.112 (6), p.4640-4646
Main Authors: El-Khazragy, Nashwa, Mohammed, Hayam Fathy, Yassin, Mohamed, Elghoneimy, K.K., Bayoumy, Walid, Hewety, Amr, El Magdoub, Hekmat M., Elayat, Wael, Zaki, Walid, Safwat, Gehan, Mosa, Mai, Zedan, Khouloud, Salem, Salema, Bannunah, Azzah M., Mansy, Azza
Format: Article
Language:English
Subjects:
Cisplatin resistance
Lnc-MEG3
Lnc-PVT1
Lnc-TUG1
Long non-coding RNA
Ovarian cancer
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Summary:The current study aimed to investigate the potentiality of three lncRNAs “Plasmacytoma variant translocation 1(lnc-PVT1), Taurine upregulated gene type 1(lnc-TUG1) and Maternally expressed gene 3 (lnc-MEG-3)”, to predict Cisplatin resistance in ovarian cancer (OC), in addition, to access their prognostic significance. The expression level of lncRNAs were measured in 100 formalin-fixed paraffin-embedded tissue (FFET) samples of OC patients who were treated by Cisplatin-based chemotherapy using qPCR. The results showed that lnc_PVT1 was significantly upregulated by 2.3 folds in Cisplatin resistant tissues, while, lnc-TUG1 and lnc-MEG3 were downregulated by 1.2 and 3 folds, respectively. In addition, the three lncRNAs exhibited high sensitivity and specificity in predicting chemo-resistance and they were negatively associated with OS and progression-free survival (p 
ISSN:0888-7543
1089-8646
DOI:10.1016/j.ygeno.2020.08.005