Zinc deficiency limiting head growth to discharge in extremely low gestational age infants with insufficient linear growth: a cohort study

Objective To assess the relationship of size for age with zinc deficiency in extremely low gestational age (GA) infants (23–28 weeks, ELGANs) who had insufficient linear growth despite optimizing other nutrients and to analyze changes in fronto-occipital circumference (FOC), weight and length with z...

Full description

Saved in:
Bibliographic Details
Published in:Journal of perinatology 2020-11, Vol.40 (11), p.1694-1704
Main Authors: Brion, Luc P., Heyne, Roy, Steven Brown, L., Lair, Cheryl S., Edwards, Audrey, Burchfield, Patti J., Caraig, Maria
Format: Article
Language:English
Subjects:
692/308/409
692/699/1702
Age
Cohort analysis
Comparative analysis
Discharge
Gestational age
Growth
Infants
Medicine
Medicine & Public Health
Nutrient deficiency
Nutrients
Pediatric Surgery
Pediatrics
Physical growth
Supplements
Weight
Zinc
Zinc compounds
Zinc in the body
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To assess the relationship of size for age with zinc deficiency in extremely low gestational age (GA) infants (23–28 weeks, ELGANs) who had insufficient linear growth despite optimizing other nutrients and to analyze changes in fronto-occipital circumference (FOC), weight and length with zinc supplementation. Study design Retrospective cohort study. Results Among 302 ELGANs, a serum zinc concentration was obtained in 52 with insufficient linear growth (17%). Zinc deficiency (serum concentration 2 weeks improved FOC growth to discharge or 50 weeks postmenstrual age in infants with Zn deficiency. However, neither linear growth nor weight gain improved with Zn supplementation. Conclusion Zinc deficiency was diagnosed in 14% ELGANs in this cohort. Zinc supplementation for >2 weeks improved FOC growth but not linear growth or weight gain.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-00778-w