Naturally Occurring Stable Calcium Isotope Ratios in Body Compartments Provide a Novel Biomarker of Bone Mineral Balance in Children and Young Adults

ABSTRACT Serum calcium (Ca), bone biomarkers, and radiological imaging do not allow accurate evaluation of bone mineral balance (BMB), a key determinant of bone mineral density (BMD) and fracture risk. We studied naturally occurring stable (non‐radioactive) Ca isotopes in different body pools as a p...

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Bibliographic Details
Published in:Journal of bone and mineral research 2021-01, Vol.36 (1), p.133-142
Main Authors: Shroff, Rukshana, Fewtrell, Mary, Heuser, Alexander, Kolevica, Ana, Lalayiannis, Alexander, McAlister, Louise, Silva, Selmy, Goodman, Nadine, Schmitt, Claus P, Biassoni, Lorenzo, Rahn, Anja, Fischer, Dagmar‐Christiane, Eisenhauer, Anton
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biomarkers
Bone growth
Bone imaging
Bone mass
BONE MINERAL BALANCE
BONE MINERAL DENSITY
Bone resorption
Bone turnover
CALCIUM
Calcium (blood)
Children
Computed tomography
Dual energy X-ray absorptiometry
Feces
Homeostasis
Ionization
ISOTOPES
Mineralization
Osteogenesis
Parathyroid
Parathyroid hormone
PERIPHERAL QUANTITATIVE CT SCAN
Urine
Young adults
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Summary:ABSTRACT Serum calcium (Ca), bone biomarkers, and radiological imaging do not allow accurate evaluation of bone mineral balance (BMB), a key determinant of bone mineral density (BMD) and fracture risk. We studied naturally occurring stable (non‐radioactive) Ca isotopes in different body pools as a potential biomarker of BMB. 42Ca and 44Ca are absorbed from our diet and sequestered into different body compartments following kinetic principles of isotope fractionation; isotopically light 42Ca is preferentially incorporated into bone, whereas heavier 44Ca preferentially remains in blood and is excreted in urine and feces. Their ratio (δ44/42Ca) in serum and urine increases during bone formation and decreases with bone resorption. In 117 healthy participants, we measured Ca isotopes, biomarkers, and BMD by dual‐energy X‐ray absorptiometry (DXA) and tibial peripheral quantitative CT (pQCT). 44Ca and 42Ca were measured by multi‐collector ionization‐coupled plasma mass‐spectrometry in serum, urine, and feces. The relationship between bone Ca gain and loss was calculated using a compartment model. δ44/42Caserum and δ44/42Caurine were higher in children (n = 66, median age 13 years) compared with adults (n = 51, median age 28 years; p
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.4158