Tandem Synthesis of 2‑Carboxybenzofurans via Sequential Cu-Catalyzed C–O Coupling and Mo(CO)6‑Mediated Carbonylation Reactions

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C–O coupling and Mo­(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionali...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-09, Vol.85 (17), p.11490-11500
Main Authors: Mo, Qinliang, Sun, Nan, Jin, Liqun, Hu, Baoxiang, Shen, Zhenlu, Hu, Xinquan
Format: Article
Language:English
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Summary:A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C–O coupling and Mo­(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c01620