Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery

Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and synthetic organic compounds. Statistically, DE is the second most popular and enduring scaffold within the numerous medicinal chemistry and agrochemical reports. Given its unique physicochemical properties...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2020-09, Vol.68 (37), p.9839-9877
Main Authors: Chen, Tao, Xiong, Hao, Yang, Jing-Fang, Zhu, Xiao-Lei, Qu, Ren-Yu, Yang, Guang-Fu
Format: Article
Language:English
Subjects:
Agrochemicals - chemistry
Agrochemicals - pharmacology
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Drug Discovery
Ethers - chemistry
Ethers - pharmacology
Humans
Structure-Activity Relationship
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Summary:Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and synthetic organic compounds. Statistically, DE is the second most popular and enduring scaffold within the numerous medicinal chemistry and agrochemical reports. Given its unique physicochemical properties and potential biological activities, DE nucleus is recognized as a fundamental element of medicinal and agrochemical agents aimed at different biological targets. Its drug-like derivatives have been extensively synthesized with interesting biological features including anticancer, anti-inflammatory, antiviral, antibacterial, antimalarial, herbicidal, fungicidal, insecticidal, and so on. In this review, we highlight the medicinal and agrochemical versatility of the DE motif according to the published information in the past decade and comprehensively give a summary of the target recognition, structure–activity relationship (SAR), and mechanism of action of its analogues. It is expected that this profile may provide valuable guidance for the discovery of new active ingredients both in drug and pesticide research.
ISSN:0021-8561
1520-5118
DOI:10.1021/acs.jafc.0c03369