Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery

• Published in: Journal of agricultural and food chemistry 2020-09, Vol.68 (37), p.9839-9877
• Main Authors: Chen, Tao, Xiong, Hao, Yang, Jing-Fang, Zhu, Xiao-Lei, Qu, Ren-Yu, Yang, Guang-Fu
• Format: Article
• Language: English
• Subjects: Agrochemicals - chemistry; Agrochemicals - pharmacology; Animals; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Drug Discovery; Ethers - chemistry; Ethers - pharmacology; Humans; Structure-Activity Relationship
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.0c03369

Diaryl ether (DE) is a functional scaffold existing widely both in natural products (NPs) and synthetic organic compounds. Statistically, DE is the second most popular and enduring scaffold within the numerous medicinal chemistry and agrochemical reports. Given its unique physicochemical properties and potential biological activities, DE nucleus is recognized as a fundamental element of medicinal and agrochemical agents aimed at different biological targets. Its drug-like derivatives have been extensively synthesized with interesting biological features including anticancer, anti-inflammatory, antiviral, antibacterial, antimalarial, herbicidal, fungicidal, insecticidal, and so on. In this review, we highlight the medicinal and agrochemical versatility of the DE motif according to the published information in the past decade and comprehensively give a summary of the target recognition, structure–activity relationship (SAR), and mechanism of action of its analogues. It is expected that this profile may provide valuable guidance for the discovery of new active ingredients both in drug and pesticide research.