Microbiome governs cancer mutations

A recent study found that a bacterial metabolite is necessary to execute the cancer driving potential of ‘hotspot’ mutations in the p53 tumour suppressor gene.

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Bibliographic Details
Published in:Nature reviews. Microbiology 2020-10, Vol.18 (10), p.542-543
Main Author: Sridhar, Akila
Format: Article
Language:English
Subjects:
631/326/2565/2134
631/67
Biomedical and Life Sciences
Cancer
Gastrointestinal Microbiome - genetics
Gene mutations
Genetic aspects
Health aspects
Humans
Infectious Diseases
Life Sciences
Medical Microbiology
Metabolites
Microbiology
Microbiomes
Microbiota (Symbiotic organisms)
Microbiota - genetics
Mutation
Mutation hot spots
Neoplasms - genetics
p53 Protein
Parasitology
Research Highlight
Tumor Suppressor Protein p53
Tumors
Virology
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Description
Summary:A recent study found that a bacterial metabolite is necessary to execute the cancer driving potential of ‘hotspot’ mutations in the p53 tumour suppressor gene.
ISSN:1740-1526
1740-1534
DOI:10.1038/s41579-020-0434-8