Blood pressure control is not enough to normalize endothelial repair by progenitor cells

As individuals who present with risk factors within acceptable or average value ranges often develop cardiovascular (CV) disease, it has been suggested that other CV risk factors need to be considered in addition to those that are commonly combined in the Framingham score (FS) to estimate the risk o...

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Published in:American journal of physiology. Heart and circulatory physiology 2020-10, Vol.319 (4), p.H744-H752
Main Authors: de Cavanagh, Elena M. V., González, Sergio A., Inserra, Felipe, Forcada, Pedro, Castellaro, Carlos, Chiabaut-Svane, Jorge, Obregón, Sebastián, Casarini, María Jesús, Kempny, Pablo, Kotliar, Carol
Format: Article
Language:English
Subjects:
Arteriosclerosis
Atherosclerosis
Blood pressure
Cardiovascular diseases
Cell culture
Cells (biology)
Diameters
Extracellular matrix
Femur
Health risks
Hemopoiesis
Hypertension
Impairment
Peripheral blood
Progenitor cells
Repair
Risk analysis
Risk factors
Wave velocity
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Summary:As individuals who present with risk factors within acceptable or average value ranges often develop cardiovascular (CV) disease, it has been suggested that other CV risk factors need to be considered in addition to those that are commonly combined in the Framingham score (FS) to estimate the risk of general CV disease. We investigated whether peripheral endothelial progenitor cells (EPCs) and tunneling nanotubes (TNTs) deserve to be considered. Here we report that EPCs and TNTs are significantly lower in controlled hypertensive patients versus normotensive subjects and that the disparity in vascular status between patients presenting with an FS of ≥10% with scarce vascular changes and those presenting with an FS of
ISSN:0363-6135
1522-1539
DOI:10.1152/ajpheart.00333.2020