Echocardiographic assessment of hemodynamic changes in preterm neonates with shock: a prospective pragmatic cohort study

• Published in: European journal of pediatrics 2020-12, Vol.179 (12), p.1893-1899
• Main Authors: Pawale, Dinesh, Murki, Srinivas, Kulkarni, Dattatray, Vardhelli, Venkateshwarlu, Sharma, Deepak, Oleti, Tejopratap, Kiran, Sai, Bakhru, Shweta, Koneti, Nageswar Rao
• Format: Article
• Language: English
• Subjects: Cohort analysis; Doppler effect; Echocardiography; Heart; Infants; Management; Medicine; Medicine & Public Health; Neonates; Newborn babies; Original Article; Pediatrics; Shock; Statistical analysis; Ventricle
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/s00431-020-03775-5

Shock is a state of circulatory dysfunction and its diagnosis is complex in neonates. Hemodynamic assessment using echocardiography has potential to guide better management regimes in neonates with shock. Objective of this study is to analyze changes in the echocardiographic parameters in preterm neonates with shock at presentation and after resolution. In this prospective pragmatic Cohort study, eligible neonates with shock were monitored for changes in echocardiographic parameters at onset of shock and after resolution of shock. Paired data analysis was done for observed changes in the parameters. Based on initial clinical parameters and echocardiographic parameters, infants were assigned into different types of shock. Data of 37 infants were analyzed for baseline clinical and echocardiographic parameters, and data of 31 infants were analyzed for the changes in the observed parameters after shock resolution. Statistically significant changes were observed in inferior vena cava collapsibility index (ICI), left ventricular end diastolic volume (LVEDV), isovolemic ventricular relaxation time (IVRT), left and right ventricular stroke volume, and ejection fraction (EF). There was no agreement between clinical and echocardiographic definitions of shock. Conclusion : We noticed shock has overlapping pathophysiologic features. Our study highlights the importance of baseline documentation of echocardiographic parameters of all infants who are at risk of shock and repeat echocardiography at onset of shock to observe the changes in ICI, LVEDV, IVRT, stroke volume, and EF. This would guide pathophysiological management of shock in neonates. What is Known: • In neonates pathophysiology of shock is overlapping. • Echocardiography can help in better understanding and management of shock. What is New: • Study gives median changes in major echocardiographic parameters in neonatal shock. • These changes can guide for selection of volume and inotropes in management.