Photocatalytic Hydroacylation of Alkenes by Directly Using Acyl Oximes

Acyl oximes are directly used as the acyl radical precursors in the hydroacylation reactions for the first time. In this work, acyl radicals can be effectively generated via β-scission of a phosphoranyl radical under photocatalytic conditions. As a result, the hydroacylation of alkenes triggered by...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-09, Vol.85 (18), p.11989-11996
Main Authors: Zheng, Lan, Xia, Peng-Ju, Zhao, Qing-Lan, Qian, Yu-En, Jiang, Wen-Nian, Xiang, Hao-Yue, Yang, Hua
Format: Article
Language:English
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Summary:Acyl oximes are directly used as the acyl radical precursors in the hydroacylation reactions for the first time. In this work, acyl radicals can be effectively generated via β-scission of a phosphoranyl radical under photocatalytic conditions. As a result, the hydroacylation of alkenes triggered by the resulting acyl radicals leads to facile syntheses of a range of valuable ketones.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.0c01818