Transcriptomic and proteomic profiling response of methicillin-resistant Staphylococcus aureus (MRSA) to a novel bacteriocin, plantaricin GZ1-27 and its inhibition of biofilm formation

Methicillin-resistant Staphylococcus aureus (MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in respon...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2020-09, Vol.104 (18), p.7957-7970
Main Authors: Du, Hechao, Zhou, Libang, Lu, Zhaoxin, Bie, Xiaomei, Zhao, Haizhen, Niu, Yan D., Lu, Fengxia
Format: Article
Language:English
Subjects:
Amino acids
Anti-Bacterial Agents - pharmacology
Bacteriocins
Bacteriocins - genetics
Biofilms
Biomedical and Life Sciences
Biosynthesis
Biotechnology
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA repair
DNA replication
Drug resistance in microorganisms
Genes
Genomics
Life Sciences
Metabolic pathways
Metabolism
Metabolites
Methicillin
Methicillin-Resistant Staphylococcus aureus - genetics
Microbial Genetics and Genomics
Microbial Sensitivity Tests
Microbiology
Microscopy
Minimum inhibitory concentration
Multidrug resistance
Plant metabolites
Protein folding
Proteins
Proteomics
Scanning electron microscopy
Scanning microscopy
Secondary metabolites
Staphylococcus aureus
Staphylococcus infections
Transcriptome
Transcriptomics
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Summary:Methicillin-resistant Staphylococcus aureus (MRSA) has become a worrisome superbug, due to its wide distribution and multidrug resistance. To characterize effects of a newly identified plantaricin GZ1-27 on MRSA, transcriptomic and proteomic profiling of MRSA strain ATCC43300 was performed in response to sub-MIC (16 μg/mL) plantaricin GZ1-27 stress. In total, 1090 differentially expressed genes ( padj   1.2, p  
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-020-10589-w