The role of mitochondrial dysfunction in mesenchymal stem cell senescence

Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limitin...

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Bibliographic Details
Published in:Cell and tissue research 2020-12, Vol.382 (3), p.457-462
Main Authors: Wang, Yibo, Liu, Yunlong, Chen, Erman, Pan, Zhijun
Format: Article
Language:English
Subjects:
B cells
Biomedical and Life Sciences
Biomedicine
Cell self-renewal
Degenerative diseases
Energy metabolism
Human Genetics
Medical colleges
Mesenchymal stem cells
Mini Review
Mitochondria
Molecular Medicine
Oxidative metabolism
Oxidative phosphorylation
Phosphorylation
Physiological aspects
Proteomics
Senescence
Stem cells
Tricarboxylic acid cycle
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Summary:Mesenchymal stem cells (MSCs) hold enormous potential for the treatment of immune-related conditions and degenerative diseases, owing to their self-renewal and multilineage differentiation capabilities. Nevertheless, cellular senescence significantly impacts the quantity and quality of MSCs, limiting their clinical use. Mitochondria play essential roles in energy production by oxidative phosphorylation and metabolism of energy sources via the tricarboxylic acid cycle. Therefore, mitochondrial dysfunction is a primary cause of senescence in MSCs. Herein, we summarize the current knowledge regarding the mechanisms underlying mitochondrial dysfunction–associated cellular senescence. We also discuss potential methods to prevent or even reverse MSC senescence.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-020-03272-z