Stress‐induced cortisol modulates the control of memory retrieval towards the dorsal striatum

• Published in: The European journal of neuroscience 2022-05, Vol.55 (9-10), p.2699-2713
• Main Authors: Zerbes, Gundula, Kausche, Franziska M., Schwabe, Lars
• Format: Article
• Language: English
• Subjects: Amygdala; Bias; Caudate-putamen; cognitive; Cognitive ability; Cortisol; glucocorticoids; habit; Hippocampus; Hormones; Humans; Hydrocortisone; Learning; Magnetic resonance imaging; Memory; multiple memory systems; Neostriatum
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.14942

Stress can modulate the recruitment of multiple memory systems during learning, favouring dorsal striatal “habit” learning over hippocampal “cognitive” learning. Here, we tested whether stress may also bias the engagement of “cognitive” and “habit” systems during retrieval and thereby affect the nature of remembering. To this end, participants first performed a probabilistic classification learning task that can be solved by both the “cognitive” and the “habit” system. Twenty‐four hours later, participants underwent either a stress manipulation or a non‐stressful control procedure before they completed a retention test for the previously learned task in the MRI scanner. During this retention test, stress‐induced cortisol levels were linked to a relative bias towards behavioural strategies indicative for the “habit” system. At the neural level, stress led to increased dorsal striatal activity during retrieval. Elevated cortisol levels were directly correlated with increased activity in the dorsal striatum and further linked to reduced functional connectivity between the hippocampus and the amygdala, which is assumed to orchestrate the stress‐related shift from “cognitive” to “habitual” control. Together, our data suggest that stress may bias the contributions of multiple memory systems also at retrieval, in a manner that promotes dorsal striatal “habit” processes and most likely driven by cortisol.