The implementation of an aminoglycoside induced ototoxicity algorithm for people with cystic fibrosis

Aminoglycoside antibiotics treat respiratory infections in cystic fibrosis (CF). An aminoglycoside induced ototoxicity algorithm (AIOA) was implemented to assess ototoxicity among people with CF treated with intravenous and/or inhaled aminoglycosides. Prior to AIOA implementation, 14 of 52 patients...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cystic fibrosis 2021-03, Vol.20 (2), p.284-287
Main Authors: Elson, E. Claire, Meier, Ellen, Oermann, Christopher M.
Format: Article
Language:English
Subjects:
Adolescent
Algorithms
Aminoglycoside
Aminoglycosides - adverse effects
Audiometry, Pure-Tone
Cystic fibrosis
Cystic Fibrosis - complications
Female
Humans
Male
Ototoxicity
Respiratory Tract Infections - drug therapy
Respiratory Tract Infections - microbiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aminoglycoside antibiotics treat respiratory infections in cystic fibrosis (CF). An aminoglycoside induced ototoxicity algorithm (AIOA) was implemented to assess ototoxicity among people with CF treated with intravenous and/or inhaled aminoglycosides. Prior to AIOA implementation, 14 of 52 patients (27%) treated with intravenous aminoglycosides had an audiogram. In the 24 months post AIOA implementation, 43 of 44 patients (98%) treated with intravenous aminoglycosides had an audiogram, with 27 (63%) demonstrating abnormalities. Prior to AIOA development, 18 of 70 patients (26%) who received at least two courses of inhaled aminoglycosides had an audiogram. Post AIOA implementation, 33 patients qualified for an audiogram after receiving inhaled aminoglycosides. Of these, 19 (58%) had an audiogram and 10 (53%) had abnormalities. Overall, we identified 46 (61%) people with CF with hearing abnormalities compared to 2.4% in the CF Foundation Patient Registry. This suggests an urgent need for CF programs to implement AIOAs.
ISSN:1569-1993
1873-5010
DOI:10.1016/j.jcf.2020.08.002