Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey

Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spo...

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Published in:Journal of physiology and biochemistry 2020-11, Vol.76 (4), p.561-572
Main Authors: López-González, Manuel Víctor, González-García, Marta, Peinado-Aragonés, Carlos Antonio, Barbancho, Miguel Ángel, Díaz-Casares, Amelia, Dawid-Milner, Marc Stefan
Format: Article
Language:English
Subjects:
Animal Physiology
Biomedical and Life Sciences
Biomedicine
Human Physiology
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Summary:Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. Accordingly, we have studied the interactions between dlPAG and A5 region in spontaneously breathing anesthetized rats. dlPAG was electrically stimulated (20–30 μA 1-ms pulses were given for 5 s at 100 Hz). Changes in the evoked cardiorespiratoy response were analysed before and after ipsilateral microinjections of muscimol (GABAergic agonist, 50 nl, 0.25 nmol, 5 s) within the A5 region. Electrical stimulation of the dlPAG produces, in the rat, a response characterized by tachypnoea ( p  
ISSN:1138-7548
1877-8755
DOI:10.1007/s13105-020-00761-1