Titanium dioxide nanoparticles-induced cytogenotoxicity and alterations in haematological indices of Clarias gariepinus (Burchell, 1822)

The application of titanium dioxide (TiO2) nanoparticles (NPs) in the manufacturing of consumer products has increased tremendously and with the potential to induce deleterious effects on aquatic biota. There have been reports on metal oxide NP toxicity in aquatic organisms, however, information on...

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Bibliographic Details
Published in:Toxicology and industrial health 2020-10, Vol.36 (10), p.807-815
Main Authors: Ogunsuyi, Opeoluwa M, Adegoye, Elizabeth O, Ogunsuyi, Olusegun I, Alabi, Okunola A, Alimba, Chibuisi G, Bakare, Adekunle A
Format: Article
Language:English
Subjects:
Aquatic animals
Aquatic biota
Aquatic organisms
Benzene
Biodiversity
Biota
Catfish
Cell size
Clarias gariepinus
Consumer products
Cytogenetics
Cytotoxicity
Dechlorination
Drinking water
Erythrocytes
Exposure
Genotoxicity
Hematocrit
Hematology
Hemoglobin
Leukocytes (neutrophilic)
Lymphocytes
Metal oxides
Nanoparticles
Platelets
Titanium
Titanium dioxide
Toxicity
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Summary:The application of titanium dioxide (TiO2) nanoparticles (NPs) in the manufacturing of consumer products has increased tremendously and with the potential to induce deleterious effects on aquatic biota. There have been reports on metal oxide NP toxicity in aquatic organisms, however, information on cytotoxicity and genotoxicity of TiO2 NPs on the African catfish, Clarias gariepinus, is scarce. In this study, we investigated the genotoxicity and haematotoxicity of TiO2 NPs in C. gariepinus using the micronucleus (MN) assay and haematological analysis, respectively. Juvenile C. gariepinus were exposed to 6.25, 12.5, 25.0, 50.0 and 100.0 mg L−1 concentrations of TiO2 NPs for 7 and 28 days. Benzene (0.05 mL L−1) and dechlorinated tap water were used as positive and negative controls, respectively. Data of the MN showed a significant (p < 0.05) concentration-dependent increase in the frequency of MN at both exposure periods in comparison to negative control. Red blood cells, haematocrit, platelets and heterophils significantly reduced with an increased mean corpuscular haemoglobin concentration and lymphocytes at the 7-day exposure period, while in the 28-day exposure period, mean cell volume, mean corpuscular haemoglobin and lymphocytes had a significant increase in comparison with the negative control. This study indicates that TiO2 NPs induced cytogenetic and haematological alterations in C. gariepinus and is of relevance in biodiversity and aquatic health management.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233720948682