Vitreous levels of vascular endothelial growth factor, stromal cell–derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy

Purpose To determine the vitreous levels of vascular endothelial growth factor (VEGF), stromal cell–derived factor-1α (SDF-1α) and angiopoietin-like protein 2 (ANGPTL2) in patients with active proliferative diabetic retinopathy (PDR), and to ascertain their contribution on different clinical present...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2021, Vol.259 (1), p.53-60
Main Authors: Keles, Ali, Sonmez, Kenan, Erol, Yasemin Ozdamar, Ayyıldız, Sema Nur, Ogus, Elmas
Format: Article
Language:English
Subjects:
Angiopoietin
Angiopoietin-Like Protein 2
Angiopoietin-like Proteins
Case-Control Studies
Chemokine CXCL12
Chemokines
Diabetes
Diabetes Mellitus
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Diabetic Retinopathy - surgery
Enzyme-Linked Immunosorbent Assay
Eye
Hemorrhage
Humans
Medicine
Medicine & Public Health
Ophthalmology
Retinal Disorders
Retinopathy
Stromal Cells
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A
Vitrectomy
Vitreous Body
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Summary:Purpose To determine the vitreous levels of vascular endothelial growth factor (VEGF), stromal cell–derived factor-1α (SDF-1α) and angiopoietin-like protein 2 (ANGPTL2) in patients with active proliferative diabetic retinopathy (PDR), and to ascertain their contribution on different clinical presentation of active PDR. Methods This case–control study included 31 eyes with active PDR and 10 eyes with idiopathic macular hole (MH) (control group). Eyes with active PDR were divided into three subgroups: vitreous hemorrhage (VH), tractional retinal detachment (TRD) caused by active fibrovascular membrane (FVM), and coexistence of VH and TRD with FVM. Vitreous samples obtained during vitrectomy were analyzed for concentrations of VEGF, SDF-1α, and ANGPTL2. Results Vitreous level of VEGF (2021 (168–6550) pg/ml vs 110.1 (74.5–236) pg/ml), SDF-1α (517 (194–1044) pg/ml vs 388 (320–535) pg/ml), and ANGPTL2 (725 (131–1590) ng/ml vs 196 (75.9–437) ng/ml) were significantly higher in eyes with active PDR than in control group ( p  
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-020-04889-0