Dietary Inflammatory Index and the Risk of Frailty Among Older Adults: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis was conducted to comprehensively examine the association between Dietary Inflammatory Index (DII®) score and risk of frailty. Frailty risk were available from five studies comprising 13,908 older adults. Furthermore, frailty related parameters were extacted from...

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Bibliographic Details
Published in:Research on aging 2021-08, Vol.43 (7-8), p.323-331
Main Authors: Moradi, Sajjad, Hadi, Amir, Mohammadi, Hamed, Asbaghi, Omid, Zobeiri, Mehdi, Marx, Wolfgang, Entezari, Mohammad Hassan
Format: Article
Language:English
Subjects:
Body weight
Cohort analysis
Fatigue
Frailty
Indexes
Meta-analysis
Odds ratio analysis
Older people
Physical activity
Risk
Strength
Systematic review
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Summary:A systematic review and meta-analysis was conducted to comprehensively examine the association between Dietary Inflammatory Index (DII®) score and risk of frailty. Frailty risk were available from five studies comprising 13,908 older adults. Furthermore, frailty related parameters were extacted from two studies with 7,539 individuals. A pooled adjusted odds ratio analysis indicated that there was an association between DII® score and frailty risk (OR = 1.24, 95%CI: 1.6–1.33, P < 0.001, I2 = 0.0%). The results of frailty related parameters demonstrated that DII® score was associated with weakness risk (OR = 1.12, 95%CI: 1.05–1.19, P = 0.014, I2 = 0.0%), but not other frailty-related parameters including exhaustion, low BMI or low physical activity. The results of this meta-analysis suggest that older adults who exhibit higher DII® scores have an increased frailty risk. Further prospective cohort studies with longer follow-up periods, are needed to support this possible association between DII® score and frailty risk.
ISSN:0164-0275
1552-7573
DOI:10.1177/0164027520948176