Age-related features in vestibular migraine onset: A multiparametric analysis

• Published in: Cephalalgia 2020-12, Vol.40 (14), p.1605-1613
• Main Authors: Ori, Michele, Arra, Gabriele, Caricato, Michela, Freccia, Rocco, Frati, Francesco, De Bonis, Teodosio, Ricci, Giampietro, Faralli, Mario
• Format: Article
• Language: English
• Subjects: Adult; Dizziness; Female; Humans; Male; Middle Aged; Migraine Disorders - epidemiology; Retrospective Studies; Vertigo; Vestibular Diseases - complications; Vestibular Diseases - diagnosis; Vestibular Diseases - epidemiology
• ISSN: 0333-1024; 1468-2982
• DOI: 10.1177/0333102420951505

Background Clinical heterogeneity is a peculiarity of vestibular migraine, in contrast to other vestibular disorders that have a more stereotypical expression. Migraine presents a range of variability in symptoms depending on the age of the patient. Supposing that migraine headache and vestibular migraine share the same pathogenetic mechanisms, a multiparametric analysis was performed to verify the hypotheses of an age-related influence on the clinical features of vestibular migraine at the onset. Methods In this retrospective study, we analysed the clinical records of 72 consecutive patients affected by vestibular migraine from June 2012 to November 2018: 64 females and eight males; mean age 38.2 ± 9.6. We considered only patients that reported onset of vestibular symptoms within 12 months preceding inclusion into the study. Results Statistical analysis shows a significant increase in the diagnosis of probable vestibular migraine with increasing age and a decrease in vestibular migraine diagnosis (p = 0.034). The incidence of spontaneous dizziness increases with age (p = 0.012); by contrast, external spontaneous vertigo, and visually induced vertigo decrease after 40 years of age (p = 0.018), clinically characterising the onset of juvenile forms. Spontaneous vertigo, head motion-induced vertigo/dizziness, and positional vertigo did not show significant variations with age. Conclusion Our data show that the type of vestibular symptoms in vestibular migraine varies according to the age of onset.