Interleukin-6 (IL-6) response to a simulated night-shift schedule is modulated by brain-derived neurotrophic factor ( BDNF ) genotype

The gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts....

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Bibliographic Details
Published in:Chronobiology international 2020-10, Vol.37 (9-10), p.1452-1456
Main Authors: Satterfield, Brieann C, Savenkova, Marina I, Karatsoreos, Ilia N, Jackson, Melinda L, Belenky, Gregory, Van Dongen, Hans P A
Format: Article
Language:English
Subjects:
Adult
Brain-Derived Neurotrophic Factor - genetics
Circadian Rhythm - genetics
Genotype
Humans
Interleukin-6 - genetics
Male
Sleep
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Summary:The gene contains a polymorphism (Val66Met) that influences sleep and may be associated with more flexible adaptation to circadian misalignment. Fifteen adult men (10 Val/Val homozygotes, 5 Val/Met heterozygotes) participated in a laboratory study involving two 5 d cycles of simulated night shifts. Circulating interleukin-6 (IL-6) was measured from plasma, sleep was recorded polysomnographically, and performance was measured using a psychomotor vigilance test. Compared to Val/Val homozygotes, heterozygotes exhibited a blunted IL-6 temporal (diurnal) pattern, less daytime sleep restriction, and less nighttime performance impairment after the first simulated night-shift cycle. These observations suggest that heterozygotes experienced more flexible circadian adaptation.
ISSN:0742-0528
1525-6073
DOI:10.1080/07420528.2020.1803901