All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation

How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary p...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2020-08, Vol.107 (4), p.593-594
Main Authors: Frankel, Elisa B., Kurshan, Peri T.
Format: Article
Language:English
Subjects:
Calcium - metabolism
Calcium channels
Calcium channels (voltage-gated)
Calcium Channels, N-Type - genetics
Microscopy
Neurons
Neurons - metabolism
Proteins
Synapses
Synapses - metabolism
Synaptogenesis
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Summary:How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary protein. How synapses assemble remains unknown. In this issue of Neuron, Held et al. (2020) demonstrate that Cav2-type voltage-gated calcium channels do not mediate presynaptic assembly. Moreover, the channel-associated protein α2δ localizes independently, suggesting additional functions for this auxiliary protein.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2020.07.028