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Immunoregulatory protein V‐set and immunoglobulin domain‐containing 4 is overexpressed in patients with endometriosis
Aim V‐set and immunoglobulin domain‐containing 4 (VSIG4) is a potent negative regulator of T‐cell responses and is suggested to regulate antitumor immunity. This study investigates whether VSIG4 is significantly expressed in endometriosis patients and the association between VSIG4 levels and serum c...
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Published in: | The journal of obstetrics and gynaecology research 2021-01, Vol.47 (1), p.119-127 |
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container_end_page | 127 |
container_issue | 1 |
container_start_page | 119 |
container_title | The journal of obstetrics and gynaecology research |
container_volume | 47 |
creator | Jeon, Gyun‐Ho Lee, Dae Sim Byun, Jung Mi Kim, Ki Tae Jeong, Dae Hoon |
description | Aim
V‐set and immunoglobulin domain‐containing 4 (VSIG4) is a potent negative regulator of T‐cell responses and is suggested to regulate antitumor immunity. This study investigates whether VSIG4 is significantly expressed in endometriosis patients and the association between VSIG4 levels and serum cancer antigen (CA)‐125 levels, VSIG4 levels and endometriosis severity.
Methods
Tumor tissues and peripheral blood samples were obtained during surgery from 42 endometriotic cyst and 21 nonendometriotic tumor patients. The levels of VSIG4 mRNA, VSIG4 protein expression in tumor tissue and serum soluble VSIG4 concentration were compared between the two groups. After dividing the cohort using the optimized cut‐off values obtained by receiver operating characteristic curve analysis, we examined the association between VSIG4 levels and serum CA‐125 levels, VSIG4 levels and the factors indicating endometriosis severity.
Results
The expressions of VSIG4 mRNA, VSIG4 protein and serum VSIG4 concentration were significantly increased in the endometriotic cyst group compared with the control group (P = 0.001, 0.002 and 0.049, respectively). The optimized VSIG4 cut‐off values for endometriosis prediction were 0.71, 0.32 and 144.37 pg/mL, respectively. After cohort division using these values, high VSIG4 levels group showed significantly elevated CA‐125 compared with low VSIG4 level group (P = 0.010, 0.043 and 0.039, respectively). There was no association between VSIG4 levels and the factors indicating endometriosis severity.
Conclusion
The expression of VSIG4 in endometriosis patients is increased compared with nonendometriotic tumor patients, and higher VSIG4 levels are significantly associated with higher serum CA‐125 levels. VSIG4 may be importantly involved in the immunological alteration of endometriosis. |
doi_str_mv | 10.1111/jog.14439 |
format | article |
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V‐set and immunoglobulin domain‐containing 4 (VSIG4) is a potent negative regulator of T‐cell responses and is suggested to regulate antitumor immunity. This study investigates whether VSIG4 is significantly expressed in endometriosis patients and the association between VSIG4 levels and serum cancer antigen (CA)‐125 levels, VSIG4 levels and endometriosis severity.
Methods
Tumor tissues and peripheral blood samples were obtained during surgery from 42 endometriotic cyst and 21 nonendometriotic tumor patients. The levels of VSIG4 mRNA, VSIG4 protein expression in tumor tissue and serum soluble VSIG4 concentration were compared between the two groups. After dividing the cohort using the optimized cut‐off values obtained by receiver operating characteristic curve analysis, we examined the association between VSIG4 levels and serum CA‐125 levels, VSIG4 levels and the factors indicating endometriosis severity.
Results
The expressions of VSIG4 mRNA, VSIG4 protein and serum VSIG4 concentration were significantly increased in the endometriotic cyst group compared with the control group (P = 0.001, 0.002 and 0.049, respectively). The optimized VSIG4 cut‐off values for endometriosis prediction were 0.71, 0.32 and 144.37 pg/mL, respectively. After cohort division using these values, high VSIG4 levels group showed significantly elevated CA‐125 compared with low VSIG4 level group (P = 0.010, 0.043 and 0.039, respectively). There was no association between VSIG4 levels and the factors indicating endometriosis severity.
Conclusion
The expression of VSIG4 in endometriosis patients is increased compared with nonendometriotic tumor patients, and higher VSIG4 levels are significantly associated with higher serum CA‐125 levels. VSIG4 may be importantly involved in the immunological alteration of endometriosis.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.14439</identifier><identifier>PMID: 32830403</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>cancer antigen 125 ; Cysts ; Endometriosis ; Gene expression ; immunity ; Immunoglobulins ; Immunoregulation ; mRNA ; Peripheral blood ; Proteins ; regulatory T‐cell ; Surgery ; VSIG4</subject><ispartof>The journal of obstetrics and gynaecology research, 2021-01, Vol.47 (1), p.119-127</ispartof><rights>2020 Japan Society of Obstetrics and Gynecology</rights><rights>2020 Japan Society of Obstetrics and Gynecology.</rights><rights>2021 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3779-872a6bf27de6b149a1d0f14b1c963cebb5198275fbc35962b5fd919f9fd151783</citedby><cites>FETCH-LOGICAL-c3779-872a6bf27de6b149a1d0f14b1c963cebb5198275fbc35962b5fd919f9fd151783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32830403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeon, Gyun‐Ho</creatorcontrib><creatorcontrib>Lee, Dae Sim</creatorcontrib><creatorcontrib>Byun, Jung Mi</creatorcontrib><creatorcontrib>Kim, Ki Tae</creatorcontrib><creatorcontrib>Jeong, Dae Hoon</creatorcontrib><title>Immunoregulatory protein V‐set and immunoglobulin domain‐containing 4 is overexpressed in patients with endometriosis</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
V‐set and immunoglobulin domain‐containing 4 (VSIG4) is a potent negative regulator of T‐cell responses and is suggested to regulate antitumor immunity. This study investigates whether VSIG4 is significantly expressed in endometriosis patients and the association between VSIG4 levels and serum cancer antigen (CA)‐125 levels, VSIG4 levels and endometriosis severity.
Methods
Tumor tissues and peripheral blood samples were obtained during surgery from 42 endometriotic cyst and 21 nonendometriotic tumor patients. The levels of VSIG4 mRNA, VSIG4 protein expression in tumor tissue and serum soluble VSIG4 concentration were compared between the two groups. After dividing the cohort using the optimized cut‐off values obtained by receiver operating characteristic curve analysis, we examined the association between VSIG4 levels and serum CA‐125 levels, VSIG4 levels and the factors indicating endometriosis severity.
Results
The expressions of VSIG4 mRNA, VSIG4 protein and serum VSIG4 concentration were significantly increased in the endometriotic cyst group compared with the control group (P = 0.001, 0.002 and 0.049, respectively). The optimized VSIG4 cut‐off values for endometriosis prediction were 0.71, 0.32 and 144.37 pg/mL, respectively. After cohort division using these values, high VSIG4 levels group showed significantly elevated CA‐125 compared with low VSIG4 level group (P = 0.010, 0.043 and 0.039, respectively). There was no association between VSIG4 levels and the factors indicating endometriosis severity.
Conclusion
The expression of VSIG4 in endometriosis patients is increased compared with nonendometriotic tumor patients, and higher VSIG4 levels are significantly associated with higher serum CA‐125 levels. VSIG4 may be importantly involved in the immunological alteration of endometriosis.</description><subject>cancer antigen 125</subject><subject>Cysts</subject><subject>Endometriosis</subject><subject>Gene expression</subject><subject>immunity</subject><subject>Immunoglobulins</subject><subject>Immunoregulation</subject><subject>mRNA</subject><subject>Peripheral blood</subject><subject>Proteins</subject><subject>regulatory T‐cell</subject><subject>Surgery</subject><subject>VSIG4</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kc9O3DAQxq2qqMC2h74AstRLOWSxYyeOjwiVf1ppL7TXyE4mqVeJvdhO6d54hD5jnwTvLnBAYi4z0vy-T_Z8CH2lZE5Tna1cP6ecM_kBHaUuMiKK8mOaGadZRUR5iI5DWBFChaTVJ3TI8ooRTtgR2tyM42Sdh34aVHR-g9feRTAW__r_-C9AxMq22OygfnB6GtKqdaMyNu0bZ2OajO0xxyZg9wc8_F17CAGSyuK1igZsDPjBxN8YbFJC9MYFEz6jg04NAb489xn6efnj7uI6Wyyvbi7OF1nDhJBZJXJV6i4XLZSacqloSzrKNW1kyRrQuqCyykXR6YYVssx10bWSyk52LS2oqNgMfd_7po_dTxBiPZrQwDAoC24Kdc5ZWZVSFlv02xt05SZv0-sSlU5KK05kok73VONdCB66eu3NqPympqTe5pFUfb3LI7Enz46THqF9JV8CSMDZHngwA2zed6pvl1d7yyfA0pif</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Jeon, Gyun‐Ho</creator><creator>Lee, Dae Sim</creator><creator>Byun, Jung Mi</creator><creator>Kim, Ki Tae</creator><creator>Jeong, Dae Hoon</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>202101</creationdate><title>Immunoregulatory protein V‐set and immunoglobulin domain‐containing 4 is overexpressed in patients with endometriosis</title><author>Jeon, Gyun‐Ho ; Lee, Dae Sim ; Byun, Jung Mi ; Kim, Ki Tae ; Jeong, Dae Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3779-872a6bf27de6b149a1d0f14b1c963cebb5198275fbc35962b5fd919f9fd151783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cancer antigen 125</topic><topic>Cysts</topic><topic>Endometriosis</topic><topic>Gene expression</topic><topic>immunity</topic><topic>Immunoglobulins</topic><topic>Immunoregulation</topic><topic>mRNA</topic><topic>Peripheral blood</topic><topic>Proteins</topic><topic>regulatory T‐cell</topic><topic>Surgery</topic><topic>VSIG4</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeon, Gyun‐Ho</creatorcontrib><creatorcontrib>Lee, Dae Sim</creatorcontrib><creatorcontrib>Byun, Jung Mi</creatorcontrib><creatorcontrib>Kim, Ki Tae</creatorcontrib><creatorcontrib>Jeong, Dae Hoon</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeon, Gyun‐Ho</au><au>Lee, Dae Sim</au><au>Byun, Jung Mi</au><au>Kim, Ki Tae</au><au>Jeong, Dae Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoregulatory protein V‐set and immunoglobulin domain‐containing 4 is overexpressed in patients with endometriosis</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2021-01</date><risdate>2021</risdate><volume>47</volume><issue>1</issue><spage>119</spage><epage>127</epage><pages>119-127</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
V‐set and immunoglobulin domain‐containing 4 (VSIG4) is a potent negative regulator of T‐cell responses and is suggested to regulate antitumor immunity. This study investigates whether VSIG4 is significantly expressed in endometriosis patients and the association between VSIG4 levels and serum cancer antigen (CA)‐125 levels, VSIG4 levels and endometriosis severity.
Methods
Tumor tissues and peripheral blood samples were obtained during surgery from 42 endometriotic cyst and 21 nonendometriotic tumor patients. The levels of VSIG4 mRNA, VSIG4 protein expression in tumor tissue and serum soluble VSIG4 concentration were compared between the two groups. After dividing the cohort using the optimized cut‐off values obtained by receiver operating characteristic curve analysis, we examined the association between VSIG4 levels and serum CA‐125 levels, VSIG4 levels and the factors indicating endometriosis severity.
Results
The expressions of VSIG4 mRNA, VSIG4 protein and serum VSIG4 concentration were significantly increased in the endometriotic cyst group compared with the control group (P = 0.001, 0.002 and 0.049, respectively). The optimized VSIG4 cut‐off values for endometriosis prediction were 0.71, 0.32 and 144.37 pg/mL, respectively. After cohort division using these values, high VSIG4 levels group showed significantly elevated CA‐125 compared with low VSIG4 level group (P = 0.010, 0.043 and 0.039, respectively). There was no association between VSIG4 levels and the factors indicating endometriosis severity.
Conclusion
The expression of VSIG4 in endometriosis patients is increased compared with nonendometriotic tumor patients, and higher VSIG4 levels are significantly associated with higher serum CA‐125 levels. VSIG4 may be importantly involved in the immunological alteration of endometriosis.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>32830403</pmid><doi>10.1111/jog.14439</doi><tpages>9</tpages></addata></record> |
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subjects | cancer antigen 125 Cysts Endometriosis Gene expression immunity Immunoglobulins Immunoregulation mRNA Peripheral blood Proteins regulatory T‐cell Surgery VSIG4 |
title | Immunoregulatory protein V‐set and immunoglobulin domain‐containing 4 is overexpressed in patients with endometriosis |
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