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A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates
Detection of lead(II) (Pb 2+ ) ions in water is important for the protection of human health and environment. The growing demand for onsite detection still faces challenges for sensitive and easy-to-use methods. In this work, a novel surface plasmon resonance (SPR) biosensor based on GR-5 DNAzyme an...
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| Published in: | Analytical and bioanalytical chemistry 2020-11, Vol.412 (27), p.7525-7533 |
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| container_end_page | 7533 |
| container_issue | 27 |
| container_start_page | 7525 |
| container_title | Analytical and bioanalytical chemistry |
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| creator | Wu, Huanan Wang, Shuokang Li, Sam Fong Yau Bao, Qi Xu, Qiyong |
| description | Detection of lead(II) (Pb
2+
) ions in water is important for the protection of human health and environment. The growing demand for onsite detection still faces challenges for sensitive and easy-to-use methods. In this work, a novel surface plasmon resonance (SPR) biosensor based on GR-5 DNAzyme and gold nanoparticles (AuNPs) was developed. Thiolated DNAzyme was immobilized on the gold surface of the sensor chip followed by anchoring the substrate-functionalized AuNPs through the DNAzyme-substrate hybridization. The coupling between the localized surface plasmon (LSP) of AuNPs and the surface plasmon polaritons (SPP) on the gold sensor surface was used to improve the sensitivity. The substrate cleavage in the presence of Pb
2+
ions was catalyzed by DNAzyme, leading to the removal of AuNPs and the diminished LSP-SPP coupling. The optimal detection limit was 80 pM for the sensor fabricated with 1 μM DNAzyme, corresponding to two or three orders of magnitude lower than the toxicity levels of Pb
2+
in drinking water defined by WHO and USEPA. By tuning the surface coverage of DNAzyme, the sensitivity and dynamic range could be controlled. This sensor also featured high selectivity to Pb
2+
ions and simple detection procedure. Successful detection of Pb
2+
ions in groundwater indicates that this method has the prospect in the onsite detection of Pb
2+
ions in water. Given the variety of AuNPs and metal-specific DNAzymes, this detection strategy would lead to the development of more sensitive and versatile heavy metal sensors.
Graphical abstract |
| doi_str_mv | 10.1007/s00216-020-02887-z |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2436873111</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A637489141</galeid><sourcerecordid>A637489141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-4a0cc16de251991b5264074e052a95129461f3fa595ff87e713603252d62cabf3</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiNERUvhD3BAlriUQ4rHX0mOq9LCSlW5wNlynPEqK8de7OTQ_fV4SSkSB2RZnhk_M3pHb1W9A3oNlDafMqUMVE0ZLbdtm_r4oroABW3NlKQvn2PBzqvXOe8pBdmCelWdc9ayTvDuovIb4k2PvnYJkXg0w9V2-5GMMZCMIcdEepNxIKd8Sc5YJAdv8lTyhDkGE0rFhIF8ftgcHyesd9EPpJTjwaR5tB6JjWG_7MyM-U115ozP-Pbpvax-3N1-v_la33_7sr3Z3NdWSJhrYai1oAZkEroOellWoI1AKpnpJBTlChx3RnbSubbBBriinEk2KGZN7_hldbXOPaT4c8E862nMFr03AeOSNRNctQ0HgIJ--AfdxyWFoq5QohNSdaIp1PVK7YxHPQYX52RsOQNOY9kP3VjqG8Ub0XYgTmPZ2mBTzDmh04c0TiY9aqD6ZJ5ezdPFPP3bPH0sTe-ftCz9hMNzyx-3CsBXIJevsMP0V-x_xv4CCTWjUQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449456947</pqid></control><display><type>article</type><title>A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates</title><source>Springer Nature</source><creator>Wu, Huanan ; Wang, Shuokang ; Li, Sam Fong Yau ; Bao, Qi ; Xu, Qiyong</creator><creatorcontrib>Wu, Huanan ; Wang, Shuokang ; Li, Sam Fong Yau ; Bao, Qi ; Xu, Qiyong</creatorcontrib><description>Detection of lead(II) (Pb
2+
) ions in water is important for the protection of human health and environment. The growing demand for onsite detection still faces challenges for sensitive and easy-to-use methods. In this work, a novel surface plasmon resonance (SPR) biosensor based on GR-5 DNAzyme and gold nanoparticles (AuNPs) was developed. Thiolated DNAzyme was immobilized on the gold surface of the sensor chip followed by anchoring the substrate-functionalized AuNPs through the DNAzyme-substrate hybridization. The coupling between the localized surface plasmon (LSP) of AuNPs and the surface plasmon polaritons (SPP) on the gold sensor surface was used to improve the sensitivity. The substrate cleavage in the presence of Pb
2+
ions was catalyzed by DNAzyme, leading to the removal of AuNPs and the diminished LSP-SPP coupling. The optimal detection limit was 80 pM for the sensor fabricated with 1 μM DNAzyme, corresponding to two or three orders of magnitude lower than the toxicity levels of Pb
2+
in drinking water defined by WHO and USEPA. By tuning the surface coverage of DNAzyme, the sensitivity and dynamic range could be controlled. This sensor also featured high selectivity to Pb
2+
ions and simple detection procedure. Successful detection of Pb
2+
ions in groundwater indicates that this method has the prospect in the onsite detection of Pb
2+
ions in water. Given the variety of AuNPs and metal-specific DNAzymes, this detection strategy would lead to the development of more sensitive and versatile heavy metal sensors.
Graphical abstract</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-020-02887-z</identifier><identifier>PMID: 32829439</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analytical Chemistry ; Anchoring ; Biochemistry ; Biosensors ; Cations, Divalent - analysis ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Coupling ; DNA, Catalytic - chemistry ; Drinking water ; Food Science ; Gold ; Gold - chemistry ; Groundwater ; Heavy metals ; Hybridization ; Immobilized Nucleic Acids - chemistry ; Ions ; Laboratory Medicine ; Lead ; Lead - analysis ; Limit of Detection ; Metal Nanoparticles - chemistry ; Monitoring/Environmental Analysis ; Nanoparticles ; Onsite ; Polaritons ; Research Paper ; Resonance ; Selectivity ; Sensitivity ; Sensors ; Substrates ; Surface plasmon resonance ; Surface Plasmon Resonance - methods ; Toxicity ; Water Pollutants, Chemical - analysis</subject><ispartof>Analytical and bioanalytical chemistry, 2020-11, Vol.412 (27), p.7525-7533</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-4a0cc16de251991b5264074e052a95129461f3fa595ff87e713603252d62cabf3</citedby><cites>FETCH-LOGICAL-c451t-4a0cc16de251991b5264074e052a95129461f3fa595ff87e713603252d62cabf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32829439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Huanan</creatorcontrib><creatorcontrib>Wang, Shuokang</creatorcontrib><creatorcontrib>Li, Sam Fong Yau</creatorcontrib><creatorcontrib>Bao, Qi</creatorcontrib><creatorcontrib>Xu, Qiyong</creatorcontrib><title>A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Detection of lead(II) (Pb
2+
) ions in water is important for the protection of human health and environment. The growing demand for onsite detection still faces challenges for sensitive and easy-to-use methods. In this work, a novel surface plasmon resonance (SPR) biosensor based on GR-5 DNAzyme and gold nanoparticles (AuNPs) was developed. Thiolated DNAzyme was immobilized on the gold surface of the sensor chip followed by anchoring the substrate-functionalized AuNPs through the DNAzyme-substrate hybridization. The coupling between the localized surface plasmon (LSP) of AuNPs and the surface plasmon polaritons (SPP) on the gold sensor surface was used to improve the sensitivity. The substrate cleavage in the presence of Pb
2+
ions was catalyzed by DNAzyme, leading to the removal of AuNPs and the diminished LSP-SPP coupling. The optimal detection limit was 80 pM for the sensor fabricated with 1 μM DNAzyme, corresponding to two or three orders of magnitude lower than the toxicity levels of Pb
2+
in drinking water defined by WHO and USEPA. By tuning the surface coverage of DNAzyme, the sensitivity and dynamic range could be controlled. This sensor also featured high selectivity to Pb
2+
ions and simple detection procedure. Successful detection of Pb
2+
ions in groundwater indicates that this method has the prospect in the onsite detection of Pb
2+
ions in water. Given the variety of AuNPs and metal-specific DNAzymes, this detection strategy would lead to the development of more sensitive and versatile heavy metal sensors.
Graphical abstract</description><subject>Analytical Chemistry</subject><subject>Anchoring</subject><subject>Biochemistry</subject><subject>Biosensors</subject><subject>Cations, Divalent - analysis</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Coupling</subject><subject>DNA, Catalytic - chemistry</subject><subject>Drinking water</subject><subject>Food Science</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Groundwater</subject><subject>Heavy metals</subject><subject>Hybridization</subject><subject>Immobilized Nucleic Acids - chemistry</subject><subject>Ions</subject><subject>Laboratory Medicine</subject><subject>Lead</subject><subject>Lead - analysis</subject><subject>Limit of Detection</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Monitoring/Environmental Analysis</subject><subject>Nanoparticles</subject><subject>Onsite</subject><subject>Polaritons</subject><subject>Research Paper</subject><subject>Resonance</subject><subject>Selectivity</subject><subject>Sensitivity</subject><subject>Sensors</subject><subject>Substrates</subject><subject>Surface plasmon resonance</subject><subject>Surface Plasmon Resonance - methods</subject><subject>Toxicity</subject><subject>Water Pollutants, Chemical - analysis</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhiNERUvhD3BAlriUQ4rHX0mOq9LCSlW5wNlynPEqK8de7OTQ_fV4SSkSB2RZnhk_M3pHb1W9A3oNlDafMqUMVE0ZLbdtm_r4oroABW3NlKQvn2PBzqvXOe8pBdmCelWdc9ayTvDuovIb4k2PvnYJkXg0w9V2-5GMMZCMIcdEepNxIKd8Sc5YJAdv8lTyhDkGE0rFhIF8ftgcHyesd9EPpJTjwaR5tB6JjWG_7MyM-U115ozP-Pbpvax-3N1-v_la33_7sr3Z3NdWSJhrYai1oAZkEroOellWoI1AKpnpJBTlChx3RnbSubbBBriinEk2KGZN7_hldbXOPaT4c8E862nMFr03AeOSNRNctQ0HgIJ--AfdxyWFoq5QohNSdaIp1PVK7YxHPQYX52RsOQNOY9kP3VjqG8Ub0XYgTmPZ2mBTzDmh04c0TiY9aqD6ZJ5ezdPFPP3bPH0sTe-ftCz9hMNzyx-3CsBXIJevsMP0V-x_xv4CCTWjUQ</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Wu, Huanan</creator><creator>Wang, Shuokang</creator><creator>Li, Sam Fong Yau</creator><creator>Bao, Qi</creator><creator>Xu, Qiyong</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20201101</creationdate><title>A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates</title><author>Wu, Huanan ; Wang, Shuokang ; Li, Sam Fong Yau ; Bao, Qi ; Xu, Qiyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-4a0cc16de251991b5264074e052a95129461f3fa595ff87e713603252d62cabf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Analytical Chemistry</topic><topic>Anchoring</topic><topic>Biochemistry</topic><topic>Biosensors</topic><topic>Cations, Divalent - 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analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Huanan</creatorcontrib><creatorcontrib>Wang, Shuokang</creatorcontrib><creatorcontrib>Li, Sam Fong Yau</creatorcontrib><creatorcontrib>Bao, Qi</creatorcontrib><creatorcontrib>Xu, Qiyong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials science collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Huanan</au><au>Wang, Shuokang</au><au>Li, Sam Fong Yau</au><au>Bao, Qi</au><au>Xu, Qiyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>412</volume><issue>27</issue><spage>7525</spage><epage>7533</epage><pages>7525-7533</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Detection of lead(II) (Pb
2+
) ions in water is important for the protection of human health and environment. The growing demand for onsite detection still faces challenges for sensitive and easy-to-use methods. In this work, a novel surface plasmon resonance (SPR) biosensor based on GR-5 DNAzyme and gold nanoparticles (AuNPs) was developed. Thiolated DNAzyme was immobilized on the gold surface of the sensor chip followed by anchoring the substrate-functionalized AuNPs through the DNAzyme-substrate hybridization. The coupling between the localized surface plasmon (LSP) of AuNPs and the surface plasmon polaritons (SPP) on the gold sensor surface was used to improve the sensitivity. The substrate cleavage in the presence of Pb
2+
ions was catalyzed by DNAzyme, leading to the removal of AuNPs and the diminished LSP-SPP coupling. The optimal detection limit was 80 pM for the sensor fabricated with 1 μM DNAzyme, corresponding to two or three orders of magnitude lower than the toxicity levels of Pb
2+
in drinking water defined by WHO and USEPA. By tuning the surface coverage of DNAzyme, the sensitivity and dynamic range could be controlled. This sensor also featured high selectivity to Pb
2+
ions and simple detection procedure. Successful detection of Pb
2+
ions in groundwater indicates that this method has the prospect in the onsite detection of Pb
2+
ions in water. Given the variety of AuNPs and metal-specific DNAzymes, this detection strategy would lead to the development of more sensitive and versatile heavy metal sensors.
Graphical abstract</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32829439</pmid><doi>10.1007/s00216-020-02887-z</doi><tpages>9</tpages></addata></record> |
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| ispartof | Analytical and bioanalytical chemistry, 2020-11, Vol.412 (27), p.7525-7533 |
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| source | Springer Nature |
| subjects | Analytical Chemistry Anchoring Biochemistry Biosensors Cations, Divalent - analysis Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Coupling DNA, Catalytic - chemistry Drinking water Food Science Gold Gold - chemistry Groundwater Heavy metals Hybridization Immobilized Nucleic Acids - chemistry Ions Laboratory Medicine Lead Lead - analysis Limit of Detection Metal Nanoparticles - chemistry Monitoring/Environmental Analysis Nanoparticles Onsite Polaritons Research Paper Resonance Selectivity Sensitivity Sensors Substrates Surface plasmon resonance Surface Plasmon Resonance - methods Toxicity Water Pollutants, Chemical - analysis |
| title | A label-free lead(II) ion sensor based on surface plasmon resonance and DNAzyme-gold nanoparticle conjugates |
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